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BIOMARKER:

Chr t(2;5)(p23;q35) NPM1/ALK

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Entrez ID:

Related biomarkers:

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ALK rearrangement (43)

NPM1 mutation (42)

ALK mutation (20)

ALK wild-type (18)

STRN-ALK rearrangement (10)

ALK translocation (9)

EGFR wild-type + ALK wild-type (7)

EML4-ALK rearrangement (5)

ALK G1202del (4)

ALK rearrangement + TP53 mutation (4)

FLT3 mutation + NPM1 mutation (4)

TYRO3 mutation + ALK mutation (3)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

ALK C1156Y + ALK I1171T (2)

ALK C1156Y + ALK L1198F (2)

ALK F1174L + ALK G1202R (2)

DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

ALK C1156Y + ALK G1202R (1)

ALK G1202R + ALK F1174L + ALK T1151M (1)

ALK L1152R + EGFR mutation (1)

ALK L1196M + ALK C1156Y (1)

ALK L1196M + ALK G1202R (1)

ALK L1196M + ALK L1198F (1)

ALK L1198F + ALK G1202R (1)

ALK TKD mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + HER-2 mutation (1)

ALK rearrangement + KRAS mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR mutation + ALK mutation (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EML4-ALK I1171N + EML4-ALK L1196M (1)

EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)

LMO7-ALK rearrangement (1)

PLEKHH2-ALK rearrangement (1)

RMST-ALK rearrangement (1)

TP53 G245S + ALK rearrangement (1)

FLT3-ITD F692L + NPM1 mutation (1)

IDH2 R140Q + NPM1 mutation (1)

IDH2 mutation + NPM1 mutation (1)

NPM1 exon 11 mutation (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + FLT3-TKD mutation (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

ALK mutation + TP53 mutation (0)

PTPN11 mutation + NPM1 mutation (0)

ALK rearrangement (43)

NPM1 mutation (42)

ALK mutation (20)

ALK wild-type (18)

STRN-ALK rearrangement (10)

ALK translocation (9)

EGFR wild-type + ALK wild-type (7)

EML4-ALK rearrangement (5)

ALK G1202del (4)

ALK rearrangement + TP53 mutation (4)

FLT3 mutation + NPM1 mutation (4)

TYRO3 mutation + ALK mutation (3)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

ALK C1156Y + ALK I1171T (2)

ALK C1156Y + ALK L1198F (2)

ALK F1174L + ALK G1202R (2)

DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

ALK C1156Y + ALK G1202R (1)

ALK G1202R + ALK F1174L + ALK T1151M (1)

ALK L1152R + EGFR mutation (1)

ALK L1196M + ALK C1156Y (1)

ALK L1196M + ALK G1202R (1)

ALK L1196M + ALK L1198F (1)

ALK L1198F + ALK G1202R (1)

ALK TKD mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + HER-2 mutation (1)

ALK rearrangement + KRAS mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR mutation + ALK mutation (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EML4-ALK I1171N + EML4-ALK L1196M (1)

EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)

LMO7-ALK rearrangement (1)

PLEKHH2-ALK rearrangement (1)

RMST-ALK rearrangement (1)

TP53 G245S + ALK rearrangement (1)

FLT3-ITD F692L + NPM1 mutation (1)

IDH2 R140Q + NPM1 mutation (1)

IDH2 mutation + NPM1 mutation (1)

NPM1 exon 11 mutation (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + FLT3-TKD mutation (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

ALK mutation + TP53 mutation (0)

PTPN11 mutation + NPM1 mutation (0)

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4years

Recombinant expression, characterization, and quantification in human cancer cell lines of the Anaplastic Large-Cell Lymphoma-characteristic NPM-ALK fusion protein. (PubMed, Sci Rep)

64 million molecules or 4.5 pg per lymphocyte). We also compared NPM-ALK/ β-actin ratios determined by ELISA to those independently determined by two-dimensional electrophoresis and showed that the two methods are in good agreement.

4 years ago

Journal

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ALK (Anaplastic lymphoma kinase) • NPM1 (Nucleophosmin 1)

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ALK fusion • ALK translocation • Chr t(2;5)(p23;q35) NPM1/ALK