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GENE:

SMO (Smoothened Frizzled Class Receptor)

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SMO mutation	Basal Cell Carcinoma	SMO mutation	Basal Cell Carcinoma	vismodegib Resistant: B - Late Trials vismodegib Resistant : B	vismodegib Resistant: B - Late Trials vismodegib Resistant : B
SMO mutation	Colorectal Cancer	SMO mutation	Colorectal Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
SMO P641A	Meningioma	SMO P641A	Meningioma	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3
SMO mutation	Non Small Cell Lung Cancer	SMO mutation	Non Small Cell Lung Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
SMO mutation	HER2 Positive Breast Cancer	SMO mutation	HER2 Positive Breast Cancer	trastuzumab Resistant: C3 – Early Trials trastuzumab Resistant : C3	trastuzumab Resistant: C3 – Early Trials trastuzumab Resistant : C3
SMO W535L	Basal Cell Carcinoma	SMO W535L	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO Q477E	Basal Cell Carcinoma	SMO Q477E	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO D473H	Basal Cell Carcinoma	SMO D473H	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO S533N	Basal Cell Carcinoma	SMO S533N	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO D473G	Basal Cell Carcinoma	SMO D473G	Basal Cell Carcinoma	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4	sonidegib Resistant: C4 – Case Studies sonidegib Resistant : C4
SMO D477G	Medulloblastoma	SMO D477G	Medulloblastoma	itraconazole Sensitive: D – Preclinical itraconazole Sensitive : D	itraconazole Sensitive: D – Preclinical itraconazole Sensitive : D
SMO D473H	Medulloblastoma	SMO D473H	Medulloblastoma	vismodegib Resistant: D – Preclinical vismodegib Resistant : D	vismodegib Resistant: D – Preclinical vismodegib Resistant : D