^
Association details:
| Biomarker: | SMO D473H |
|---|---|
| Cancer: | Medulloblastoma |
| Drug: | Erivedge (vismodegib) (Hedgehog cell-signalling pathway inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
Excerpt:
...in a GDC-0449–resistant mouse model of medulloblastoma...Although GDC-0449 inhibited reporter activity at an IC50 of 20 nM in SMO-WT–transfected cells, no inhibition was observed in SMO-D473H–transfected cells even at concentrations as high as 3 μM; this finding suggests that the mutation confers resistance to GDC-0449 without affecting the ability of SMO to transmit the Hh signal.
DOI:
10.1126/science.1179386
