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BIOMARKER:

PIK3CA mutation + ALK positive

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Entrez ID:

Related biomarkers:

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PIK3CA mutation + HR positive (16)

PIK3CA mutation + ER positive (10)

EML4-ALK variant 3 + TP53 mutation (5)

PIK3CA mutation + PTEN deletion (5)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

ER positive + PIK3CA H1047R (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

PIK3CA H1047R + PIK3C2B amplification (2)

PIK3CA mutation + ER negative (2)

PIK3CA mutation + HR negative (2)

PIK3CA mutation + MSI-L/dMMR (2)

TMB-H + PIK3CA mutation (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TMB-H + ALK rearrangement (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

HR positive + PIK3CA exon 10 mutation (1)

HRAS overexpression + PIK3CA amplification (1)

HRAS overexpression + PIK3CA mutation (1)

KRAS mutation + PIK3CA wild-type (1)

MET amplification + PIK3CA mutation (1)

MTAP deletion + PIK3CA mutation (1)

MYB fusion + PIK3CA mutation (1)

PD-L1 expression + PIK3CA mutation (1)

PIK3CA E542K + HR positive (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA R88Q + PD-L1 expression (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + BRAF wild-type (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA mutation + PTEN underexpression (1)

PIK3CA mutation + RAS wild-type (1)

PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA wild-type+ ESR1 wild-type (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

PD-L1 underexpression + ALK wild-type (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

MYB fusion + PIK3CA amplification (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

PIK3CA amplification + PTEN deletion (0)

PIK3CA mutation + ER negative + PGR positive (0)

PIK3CA mutation + PTEN expression (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

PIK3CA mutation + HR positive (16)

PIK3CA mutation + ER positive (10)

EML4-ALK variant 3 + TP53 mutation (5)

PIK3CA mutation + PTEN deletion (5)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

ER positive + PIK3CA H1047R (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

PIK3CA H1047R + PIK3C2B amplification (2)

PIK3CA mutation + ER negative (2)

PIK3CA mutation + HR negative (2)

PIK3CA mutation + MSI-L/dMMR (2)

TMB-H + PIK3CA mutation (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TMB-H + ALK rearrangement (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

HR positive + PIK3CA exon 10 mutation (1)

HRAS overexpression + PIK3CA amplification (1)

HRAS overexpression + PIK3CA mutation (1)

KRAS mutation + PIK3CA wild-type (1)

MET amplification + PIK3CA mutation (1)

MTAP deletion + PIK3CA mutation (1)

MYB fusion + PIK3CA mutation (1)

PD-L1 expression + PIK3CA mutation (1)

PIK3CA E542K + HR positive (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA R88Q + PD-L1 expression (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + BRAF wild-type (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA mutation + PTEN underexpression (1)

PIK3CA mutation + RAS wild-type (1)

PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA wild-type+ ESR1 wild-type (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

PD-L1 underexpression + ALK wild-type (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

MYB fusion + PIK3CA amplification (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

PIK3CA amplification + PTEN deletion (0)

PIK3CA mutation + ER negative + PGR positive (0)

PIK3CA mutation + PTEN expression (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

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PIK3CA mutation + ALK positive

Non Small Cell Lung Cancer

Resistant: C3 – Early Trials

Resistant: C3 – Early Trials