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BIOMARKER:

TP53 mutation + ALK positive

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Other names: NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor, TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
Entrez ID:
TP53 mutation + ALK positive
NSCLC
crizotinib
Sensitive: C3 – Early Trials
TP53 mutation + ALK positive
NSCLC
X-396
Resistant: C3 – Early Trials
TP53 mutation + ALK positive
NSCLC
lorlatinib
Resistant: C3 – Early Trials