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BIOMARKER:

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G

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Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor, NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor, EML4, EMAP Like 4, Restrictedly Overexpressed Proliferation-Associated Protein, Echinoderm Microtubule-Associated Protein-Like 4, Echinoderm Microtubule Associated Protein Like 4, Ropp 120, C2orf2, EMAP-4, EMAPL4, ROPP120, ELP120
Entrez ID:
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Trials
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G
LUAD
cetuximab + brigatinib
Sensitive: C3 – Early Trials
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G
LUAD
crizotinib
Resistant: C4 – Case Studies