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BIOMARKER:

PIK3CA exon 20 mutation + HR positive

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Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K, ESR1, Era, ESR, NR3A1, ER, ER beta, PGR, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3, NR3C3
Entrez ID:
PIK3CA exon 20 mutation + HR positive
HER2 Negative Breast Cancer
alpelisib
Sensitive: A2 - Guideline
PIK3CA exon 20 mutation + HR positive
CRC
cetuximab
Resistant: C3 – Early Trials
PIK3CA exon 20 mutation + HR positive
HER2 Positive Breast Cancer
everolimus
Sensitive: C4 – Case Studies