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    BIOMARKER:

    PIK3CA exon 20 mutation + HR positive

    i
    Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K, ESR1, Era, ESR, NR3A1, ER, ER beta, PGR, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3, NR3C3
    Entrez ID:
    2099; 5290; 5241
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    PIK3CA exon 20 mutation + HR positive
    HER2 Negative Breast Cancer
    alpelisib
    Sensitive: A2 - Guideline
    PIK3CA exon 20 mutation + HR positive
    CRC
    cetuximab
    Resistant: C3 – Early Trials
    PIK3CA exon 20 mutation + HR positive
    HER2 Positive Breast Cancer
    everolimus
    Sensitive: C4 – Case Studies