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BIOMARKER:

PIK3CA mutation + ER positive

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Other names: Platelet Derived Growth Factor Receptor Alpha, Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha-Type Platelet-Derived Growth Factor Receptor, CD140 Antigen-Like Family Member A, CD140a Antigen, PDGF-R-Alpha, PDGFR-2, PDGFR2, Alpha Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Alpha Receptor, PDGFR-Alpha, RHEPDGFRA, CD140A, BCR, BCR Activator Of RhoGEF And GTPase, BCR, RhoGEF And GTPase Activating Protein, Breakpoint Cluster Region Protein, Renal Carcinom
Entrez ID:
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
GDC-0032
Sensitive: B - Late Trials
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
alpelisib
Sensitive: C3 – Early Trials
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
palbociclib + GDC-0032
Sensitive: C3 – Early Trials
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
AZD5363
Sensitive: C3 – Early Trials
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
fulvestrant
Sensitive: D – Preclinical
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
everolimus
Sensitive: D – Preclinical
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
palbociclib + alpelisib
Sensitive: D – Preclinical
PIK3CA mutation + ER positive
HER2 Negative Breast Cancer
ribociclib + alpelisib
Sensitive: D – Preclinical