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BIOMARKER:

PIK3CA mutation + HR positive

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Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K, ESR1, Era, ESR, NR3A1
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Entrez ID:
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
alpelisib
Sensitive
:
A1
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
CDK6 inhibitor + alpelisib
Sensitive
:
A2
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
CDK4 inhibitor + alpelisib
Sensitive
:
A2
PIK3CA mutation + HR positive
Hormone Receptor Positive Breast Cancer
alpelisib
Sensitive
:
C1
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
GDC-0077
Sensitive
:
C2
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
palbociclib + GDC-0077
Sensitive
:
C3
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
alpelisib + GDC-0032
Sensitive
:
C3
PIK3CA mutation + HR positive
HER2 Positive Breast Cancer
trastuzumab
Resistant
:
C3
PIK3CA mutation + HR positive
HER2 Positive Breast Cancer
ado-trastuzumab emtansine
Sensitive
:
C3
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
CDK4 inhibitor
Resistant
:
C3
PIK3CA mutation + HR positive
HER2 Negative Breast Cancer
CDK6 inhibitor
Resistant
:
C3