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BIOMARKER:
EGFR mutation + BRAF V600
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor, BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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Entrez ID:
1956
;
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BRAF V600E (255)
EGFR mutation (196)
BRAF mutation (129)
BRAF V600 (106)
EGFR L858R (90)
EGFR T790M (64)
EGFR exon 20 insertion (50)
EGFR wild-type (41)
BRAF V600K (25)
BRAF wild-type (25)
EGFR L861Q (23)
EGFR C797S (22)
EGFR exon 21 mutation (20)
EGFR L858R + EGFR T790M (16)
EGFR exon 19 mutation (14)
EGFR A763_Y764insFQEA (13)
EGFR G719X (13)
EGFR S768I (12)
EGFR mutation + TP53 mutation (11)
EGFR C797S + EGFR T790M + EGFR L858R (9)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)
EGFR E746_A750del (8)
EGFR exon 20 mutation (8)
EGFRvIII mutation (8)
EGFR G719A (7)
EGFR G719S (7)
EGFR L747P (7)
EGFR exon 18 mutation (7)
EGFR wild-type + ALK wild-type (7)
BRAF G469V (7)
BRAF K601E (7)
RAS wild-type + BRAF wild-type (7)
EGFR T790M + EGFR C797S (6)
EGFR exon 19 deletion + EGFR L861Q (6)
EGFR mutation + BRAF V600E (6)
BRAF D594G (6)
BRAF V600E + RNF43 mutation (6)
EGFR G719X + EGFR S768I (5)
EGFR K745_E746insIPVAIK (5)
EGFR G719C (4)
EGFR L861Q + EGFR G719X (4)
EGFR S492R (4)
EGFR mutation + KRAS mutation (4)
EGFR mutation + PIK3CA mutation (4)
BRAF G466V (4)
BRAF V600E + PIK3CA mutation (4)
BRAF V600G (4)
NRAS mutation + BRAF mutation (4)
EGFR D770 delinsGY (3)
EGFR D770_N771insSVD (3)
EGFR E709K (3)
EGFR E709_T710delinsD (3)
EGFR E746_S752delinsV (3)
EGFR G724S (3)
EGFR H773_V774insH (3)
EGFR L718Q (3)
EGFR L833V + EGFR H835L (3)
EGFR L858R + EGFR M766Q (3)
EGFR R521K (3)
EGFR T790M negative (3)
EGFR T854A (3)
EGFR exon 18-25 duplication (3)
EGFR exon 19 deletion + EGFR C797S (3)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)
EGFR mutation + CREBBP mutation (3)
HER-2 V777L + EGFR L858R (3)
BRAF D549G (3)
BRAF G469A (3)
BRAF G469E (3)
BRAF L597Q (3)
BRAF L597R (3)
BRAF T1799A (3)
BRAF V595E (3)
BRAF V600E + TERT mutation (3)
BRAF V600R (3)
BRAF delNVTAP (3)
NRAS Q61K + BRAF V600E (3)
TERT mutation + BRAF V600E (3)
EGFR A767_V769dup (2)
EGFR D761Y (2)
EGFR D770_N771insGT (2)
EGFR E114K (2)
EGFR G465R (2)
EGFR G63R (2)
EGFR G719A + EGFR G779C (2)
EGFR G719C + EGFR S768I (2)
EGFR G719S + EGFR L861Q (2)
EGFR G874S (2)
EGFR H1975 (2)
EGFR K708R (2)
EGFR L747-S752 del (2)
EGFR L747_A750delinsP (2)
EGFR L833F + EGFR L861Q (2)
EGFR L858R + EGFR A871G (2)
EGFR L858R + EGFR L718Q (2)
EGFR L858R + RBM10 Y36* (2)
EGFR L858R + TP53 mutation (2)
EGFR L860R (2)
EGFR L861R (2)
EGFR N771delinsKG (2)
EGFR P596L (2)
EGFR R165Q (2)
EGFR R222C (2)
EGFR S645C + EGFR L858R (2)
EGFR T790M + KRAS mutation (2)
EGFR T790M + PIK3CA H1047R (2)
EGFR V802I + KRAS mutation (2)
EGFR exon 19 duplication (2)
EGFR exon 19 insertion (2)
EGFR exon 20 insertion + EGFR T790M (2)
EGFR mutation + ATM mutation (2)
EGFR mutation + CDKN2A mutation (2)
EGFR mutation + EGFR T790M (2)
EGFR mutation + MET mutation (2)
EGFR mutation + NRAS Q61K (2)
EGFR mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + ARID1A mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
EGFR mutation + TP53 mutation + NF1 mutation (2)
EGFR mutation + TP53 mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + RB1 mutation (2)
EGFR T790L (2)
EGFR delE709_T710insD (2)
KRAS mutation + EGFR wild-type (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
BRAF G466A (2)
BRAF L485W (2)
BRAF V600D (2)
BRAF V600E + MAP2K1 I111S (2)
BRAF V600M (2)
BRAF mutation + MEK1 P124L (2)
BRAF mutation + NF1 mutation (2)
BRAF rearrangement (2)
IDH1 wild-type + BRAF mutation (2)
KRAS G13D + BRAF mutation (2)
MYD88 L265P + BRAF V600E (2)
NRAS G12C + BRAF mutation (2)
ALK L1152R + EGFR mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
BRAF mutation + EGFR mutation (1)
CDK4 mutation + EGFR mutation (1)
DDR + EGFR mutation (1)
EGFR 181946 C>T (1)
EGFR A289V (1)
EGFR A750P (1)
EGFR A763V (1)
EGFR A767_V769dupASV (1)
EGFR A767dupASV (1)
EGFR A859T (1)
EGFR C796S (1)
EGFR C796S + EGFR V802I (1)
EGFR C797S + EGFR C796S (1)
EGFR C797S + EGFR exon 20 insertion (1)
EGFR D770_N771insGL (1)
EGFR D770_N771insGT + EGFR V774_C775insHV (1)
EGFR E690K (1)
EGFR E709A + EGFR G719C (1)
EGFR E709G (1)
EGFR E709Q (1)
EGFR E746 (1)
EGFR E746G (1)
EGFR E746_T751delinsl (1)
EGFR E758D (1)
EGFR E884K (1)
EGFR G2607A (1)
EGFR G709T (1)
EGFR G719A + EGFR I706T (1)
EGFR G719A + EGFR L833V (1)
EGFR G719A + EGFR R776C (1)
EGFR G719A + EGFR S768I (1)
EGFR G719A + EGFR T790M (1)
EGFR G719C + EGFR E709V (1)
EGFR G719D (1)
EGFR G719S + EGFR S768I (1)
EGFR G719X + EGFR E709F (1)
EGFR G719X + EGFR L861Q + EGFR S768I (1)
EGFR G719X + TP53 mutation (1)
EGFR G724S + EGFR R776H (1)
EGFR G735R (1)
EGFR G796S (1)
EGFR G836S (1)
EGFR H773L + EGFR V774M (1)
EGFR H773_V774insNPH (1)
EGFR H773delinsNPY (1)
EGFR H773delinsYNPY (1)
EGFR H835L (1)
EGFR I744_K745insKIPVAI (1)
EGFR K467T (1)
EGFR K757R (1)
EGFR L718V + TP53 V727M + EGFR L858R (1)
EGFR L746_T70delinsS (1)
EGFR L746_T750del (1)
EGFR L747S (1)
EGFR L747_A750>P (1)
EGFR L747_P753delinsS (1)
EGFR L747_T751delinsP (1)
EGFR L747_T751delinsS (1)
EGFR L747_T753delinsS (1)
EGFR L833V (1)
EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR L858R + EGFR C797S (1)
EGFR L858R + EGFR D761Y (1)
EGFR L858R + EGFR E709G (1)
EGFR L858R + EGFR E709X (1)
EGFR L858R + EGFR E709X + CTNNB1 mutation (1)
EGFR L858R + EGFR E884K (1)
EGFR L858R + EGFR L747V (1)
EGFR L858R + EGFR R776H (1)
EGFR L858R + EGFR S765I (1)
EGFR L858R + EGFR S768I (1)
EGFR L858R + EGFR T854A (1)
EGFR L858R + EGFR V843I (1)
EGFR L858R + EGFR exon 21 deletion (1)
EGFR L858R + FGF3 mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR L858R + RBM10 2167-1 G>T (1)
EGFR L858R + RBM10 Q255* (1)
EGFR L858R + RBM10 Q595* (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR L858R + TP53 wild-type (1)
EGFR L861P (1)
EGFR L861Q + EGFR exon 20 insertion (1)
EGFR L861Q + TP53 mutation (1)
EGFR L861Q + TP53 mutation + RB1 mutation (1)
EGFR L861X (1)
EGFR M277E (1)
EGFR M766Q (1)
EGFR M766_A767insASV (1)
EGFR N771_P772insH (1)
EGFR N771_P772insVal (1)
EGFR P546S (1)
EGFR P753S (1)
EGFR P772_H773insYNP (1)
EGFR P772_H773insYNP + EGFR H773Y (1)
EGFR P772_V774insPHV (1)
EGFR Q787Q (1)
EGFR R1052K (1)
EGFR R451C (1)
EGFR R776C + EGFR L861Q (1)
EGFR R776H (1)
EGFR R776H + EGFR C797S (1)
EGFR R776H + EGFR L861Q (1)
EGFR S464L (1)
EGFR S720I (1)
EGFR S752_I759del (1)
EGFR S768I + TP53 mutation (1)
EGFR S768_D770dup (1)
EGFR S768_D770dupSVD (1)
EGFR S768dupSVD (1)
EGFR S784F (1)
EGFR T263P (1)
EGFR T751_I759>S (1)
EGFR T790I (1)
EGFR T790M + BRAF V600E (1)
EGFR T790M + EGFR L792F (1)
EGFR T790M + EGFR L833V + EGFR H835L (1)
EGFR T790M + EGFR L861Q (1)
EGFR T790M + EGFR S768I + EGFR L858R (1)
EGFR T790M + HER-2 mutation (1)
EGFR T790M + KRAS G12V (1)
EGFR T790M + MET mutation (1)
EGFR T790M + PARP1 mutation (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR T790M + TP53 R237C (1)
EGFR T854A + EGFR T790M (1)
EGFR T858R (1)
EGFR V769A (1)
EGFR V769_770insASV (1)
EGFR V774_C775insHV (1)
EGFR V786M (1)
EGFR V802I (1)
EGFR V834L (1)
EGFR Y764_V765insHH (1)
EGFR exon 18 mutation + EGFR exon 21 mutation (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)
EGFR exon 19 deletion + EGFR T790L (1)
EGFR exon 19 deletion + TP53 exon 8 mutation (1)
EGFR exon 19 deletion + TP53 mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)
EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR exon 21 mutation + EGFR L858R (1)
EGFR mutation + ALK mutation (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
EGFR mutation + CTBP2 rs376695472 (1)
EGFR mutation + CTBP2 rs945665113 (1)
EGFR mutation + EGFR T790M + EGFR C797S (1)
EGFR mutation + FAT3 mutation (1)
EGFR mutation + GRM8 mutation (1)
EGFR mutation + HLA-DRB5 rs1071748 (1)
EGFR mutation + HLA-DRB5 rs184278615 (1)
EGFR mutation + HLA-DRB5 rs20146916 (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation + KIR3DL1 rs199822561 (1)
EGFR mutation + KIR3DL1 rs200821495 (1)
EGFR mutation + KIR3DL1 rs72629105 (1)
EGFR mutation + KIR3DL2 rs973541788 (1)
EGFR mutation + LRP1B mutation (1)
EGFR mutation + MDM4 *32C>A (1)
EGFR mutation + MET Y1003N (1)
EGFR mutation + NOTCH1 mutation (1)
EGFR mutation + RB1 mutation (1)
EGFR mutation + SMAD4 mutation (1)
EGFR mutation + TP53 exon 6 mutation (1)
EGFR mutation + TP53 exon 7 mutation (1)
EGFR mutation + UBXN11 mutation (1)
EGFR mutation + ZNF217 mutation (1)
EGFR mutation+ IDH1 R132H (1)
EGFR rearrangement (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EGFR wild-type + MET wild-type (1)
EGFR-SEPTIN14 rearrangement (1)
EGFR G729A + EGFR L858R (1)
EGFR T790M + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH2 R140W + EGFR L858R (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
MTOR L1433S + EGFR L858R + EGFR T790M (1)
AKT1 E17K + BRAF V600 (1)
BRAF 486_490 del (1)
BRAF D594N (1)
BRAF G464 (1)
BRAF G464E (1)
BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)
BRAF G466V + KIT K509Q (1)
BRAF G469R (1)
BRAF G469S (1)
BRAF G596V (1)
BRAF L505H (1)
BRAF L597K (1)
BRAF L597S (1)
BRAF N486-P490del + TP53 V157G (1)
BRAF S365L (1)
BRAF T599 (1)
BRAF V600 wild-type (1)
BRAF V600DK601del (1)
BRAF V600E + BRAF G469A + BRAF G469V (1)
BRAF V600E + BRAF K601_W604del (1)
BRAF V600E + BRAF L514V (1)
BRAF V600E + BRAF V600K (1)
BRAF V600E + KRAS G12R (1)
BRAF V600E + MSI-H/dMMR (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF V600_K601delinsE (1)
BRAF Y472C (1)
BRAF mutation + MAP2K1 mutation (1)
BRAF mutation + RAS mutation (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
BRAF mutation + TET2 mutation (1)
BRAF mutation + TP53 mutation (1)
BRAF wild-type + NRAS wild-type (1)
KRAS G12A + BRAF D549N (1)
KRAS G12V + BRAF V600E (1)
MAP2K1 V211D + BRAF mutation (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G13D + BRAF V600E (1)
RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)
ROS1 rearrangement + BRAF V600E (1)
TERT promoter mutation + BRAF V600 (1)
EGFR A839V (0)
EGFR E709A (0)
EGFR E709F (0)
EGFR G779C (0)
EGFR G873E (0)
EGFR H773L (0)
EGFR K754E (0)
EGFR L747_S752del (0)
EGFR L747_T750del (0)
EGFR L858R + EGFR G779S (0)
EGFR L858R + RBM10 Q255 (0)
EGFR R776C (0)
EGFR S765I (0)
EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)
EGFR V774M (0)
EGFR mutation + APC mutation (0)
EGFR rs4947492 (0)
MET exon 14 skipping mutation + EGFR G709T (0)
BRAF K601 (0)
BRAF L597 (0)
BRAF V600E + TERT mutation (0)
BRAF V600E + KRAS G12D (0)
BRAF V600E + MAP2K1 P124S (0)
BRAF exon 11 mutation (0)
BRAF exon 15 mutation (0)
CDKN2A mutation + BRAF V600E (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
BRAF V600E (255)
EGFR mutation (196)
BRAF mutation (129)
BRAF V600 (106)
EGFR L858R (90)
EGFR T790M (64)
EGFR exon 20 insertion (50)
EGFR wild-type (41)
BRAF V600K (25)
BRAF wild-type (25)
EGFR L861Q (23)
EGFR C797S (22)
EGFR exon 21 mutation (20)
EGFR L858R + EGFR T790M (16)
EGFR exon 19 mutation (14)
EGFR A763_Y764insFQEA (13)
EGFR G719X (13)
EGFR S768I (12)
EGFR mutation + TP53 mutation (11)
EGFR C797S + EGFR T790M + EGFR L858R (9)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)
EGFR E746_A750del (8)
EGFR exon 20 mutation (8)
EGFRvIII mutation (8)
EGFR G719A (7)
EGFR G719S (7)
EGFR L747P (7)
EGFR exon 18 mutation (7)
EGFR wild-type + ALK wild-type (7)
BRAF G469V (7)
BRAF K601E (7)
RAS wild-type + BRAF wild-type (7)
EGFR T790M + EGFR C797S (6)
EGFR exon 19 deletion + EGFR L861Q (6)
EGFR mutation + BRAF V600E (6)
BRAF D594G (6)
BRAF V600E + RNF43 mutation (6)
EGFR G719X + EGFR S768I (5)
EGFR K745_E746insIPVAIK (5)
EGFR G719C (4)
EGFR L861Q + EGFR G719X (4)
EGFR S492R (4)
EGFR mutation + KRAS mutation (4)
EGFR mutation + PIK3CA mutation (4)
BRAF G466V (4)
BRAF V600E + PIK3CA mutation (4)
BRAF V600G (4)
NRAS mutation + BRAF mutation (4)
EGFR D770 delinsGY (3)
EGFR D770_N771insSVD (3)
EGFR E709K (3)
EGFR E709_T710delinsD (3)
EGFR E746_S752delinsV (3)
EGFR G724S (3)
EGFR H773_V774insH (3)
EGFR L718Q (3)
EGFR L833V + EGFR H835L (3)
EGFR L858R + EGFR M766Q (3)
EGFR R521K (3)
EGFR T790M negative (3)
EGFR T854A (3)
EGFR exon 18-25 duplication (3)
EGFR exon 19 deletion + EGFR C797S (3)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)
EGFR mutation + CREBBP mutation (3)
HER-2 V777L + EGFR L858R (3)
BRAF D549G (3)
BRAF G469A (3)
BRAF G469E (3)
BRAF L597Q (3)
BRAF L597R (3)
BRAF T1799A (3)
BRAF V595E (3)
BRAF V600E + TERT mutation (3)
BRAF V600R (3)
BRAF delNVTAP (3)
NRAS Q61K + BRAF V600E (3)
TERT mutation + BRAF V600E (3)
EGFR A767_V769dup (2)
EGFR D761Y (2)
EGFR D770_N771insGT (2)
EGFR E114K (2)
EGFR G465R (2)
EGFR G63R (2)
EGFR G719A + EGFR G779C (2)
EGFR G719C + EGFR S768I (2)
EGFR G719S + EGFR L861Q (2)
EGFR G874S (2)
EGFR H1975 (2)
EGFR K708R (2)
EGFR L747-S752 del (2)
EGFR L747_A750delinsP (2)
EGFR L833F + EGFR L861Q (2)
EGFR L858R + EGFR A871G (2)
EGFR L858R + EGFR L718Q (2)
EGFR L858R + RBM10 Y36* (2)
EGFR L858R + TP53 mutation (2)
EGFR L860R (2)
EGFR L861R (2)
EGFR N771delinsKG (2)
EGFR P596L (2)
EGFR R165Q (2)
EGFR R222C (2)
EGFR S645C + EGFR L858R (2)
EGFR T790M + KRAS mutation (2)
EGFR T790M + PIK3CA H1047R (2)
EGFR V802I + KRAS mutation (2)
EGFR exon 19 duplication (2)
EGFR exon 19 insertion (2)
EGFR exon 20 insertion + EGFR T790M (2)
EGFR mutation + ATM mutation (2)
EGFR mutation + CDKN2A mutation (2)
EGFR mutation + EGFR T790M (2)
EGFR mutation + MET mutation (2)
EGFR mutation + NRAS Q61K (2)
EGFR mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + ARID1A mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
EGFR mutation + TP53 mutation + NF1 mutation (2)
EGFR mutation + TP53 mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + RB1 mutation (2)
EGFR T790L (2)
EGFR delE709_T710insD (2)
KRAS mutation + EGFR wild-type (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
BRAF G466A (2)
BRAF L485W (2)
BRAF V600D (2)
BRAF V600E + MAP2K1 I111S (2)
BRAF V600M (2)
BRAF mutation + MEK1 P124L (2)
BRAF mutation + NF1 mutation (2)
BRAF rearrangement (2)
IDH1 wild-type + BRAF mutation (2)
KRAS G13D + BRAF mutation (2)
MYD88 L265P + BRAF V600E (2)
NRAS G12C + BRAF mutation (2)
ALK L1152R + EGFR mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
BRAF mutation + EGFR mutation (1)
CDK4 mutation + EGFR mutation (1)
DDR + EGFR mutation (1)
EGFR 181946 C>T (1)
EGFR A289V (1)
EGFR A750P (1)
EGFR A763V (1)
EGFR A767_V769dupASV (1)
EGFR A767dupASV (1)
EGFR A859T (1)
EGFR C796S (1)
EGFR C796S + EGFR V802I (1)
EGFR C797S + EGFR C796S (1)
EGFR C797S + EGFR exon 20 insertion (1)
EGFR D770_N771insGL (1)
EGFR D770_N771insGT + EGFR V774_C775insHV (1)
EGFR E690K (1)
EGFR E709A + EGFR G719C (1)
EGFR E709G (1)
EGFR E709Q (1)
EGFR E746 (1)
EGFR E746G (1)
EGFR E746_T751delinsl (1)
EGFR E758D (1)
EGFR E884K (1)
EGFR G2607A (1)
EGFR G709T (1)
EGFR G719A + EGFR I706T (1)
EGFR G719A + EGFR L833V (1)
EGFR G719A + EGFR R776C (1)
EGFR G719A + EGFR S768I (1)
EGFR G719A + EGFR T790M (1)
EGFR G719C + EGFR E709V (1)
EGFR G719D (1)
EGFR G719S + EGFR S768I (1)
EGFR G719X + EGFR E709F (1)
EGFR G719X + EGFR L861Q + EGFR S768I (1)
EGFR G719X + TP53 mutation (1)
EGFR G724S + EGFR R776H (1)
EGFR G735R (1)
EGFR G796S (1)
EGFR G836S (1)
EGFR H773L + EGFR V774M (1)
EGFR H773_V774insNPH (1)
EGFR H773delinsNPY (1)
EGFR H773delinsYNPY (1)
EGFR H835L (1)
EGFR I744_K745insKIPVAI (1)
EGFR K467T (1)
EGFR K757R (1)
EGFR L718V + TP53 V727M + EGFR L858R (1)
EGFR L746_T70delinsS (1)
EGFR L746_T750del (1)
EGFR L747S (1)
EGFR L747_A750>P (1)
EGFR L747_P753delinsS (1)
EGFR L747_T751delinsP (1)
EGFR L747_T751delinsS (1)
EGFR L747_T753delinsS (1)
EGFR L833V (1)
EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR L858R + EGFR C797S (1)
EGFR L858R + EGFR D761Y (1)
EGFR L858R + EGFR E709G (1)
EGFR L858R + EGFR E709X (1)
EGFR L858R + EGFR E709X + CTNNB1 mutation (1)
EGFR L858R + EGFR E884K (1)
EGFR L858R + EGFR L747V (1)
EGFR L858R + EGFR R776H (1)
EGFR L858R + EGFR S765I (1)
EGFR L858R + EGFR S768I (1)
EGFR L858R + EGFR T854A (1)
EGFR L858R + EGFR V843I (1)
EGFR L858R + EGFR exon 21 deletion (1)
EGFR L858R + FGF3 mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR L858R + RBM10 2167-1 G>T (1)
EGFR L858R + RBM10 Q255* (1)
EGFR L858R + RBM10 Q595* (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR L858R + TP53 wild-type (1)
EGFR L861P (1)
EGFR L861Q + EGFR exon 20 insertion (1)
EGFR L861Q + TP53 mutation (1)
EGFR L861Q + TP53 mutation + RB1 mutation (1)
EGFR L861X (1)
EGFR M277E (1)
EGFR M766Q (1)
EGFR M766_A767insASV (1)
EGFR N771_P772insH (1)
EGFR N771_P772insVal (1)
EGFR P546S (1)
EGFR P753S (1)
EGFR P772_H773insYNP (1)
EGFR P772_H773insYNP + EGFR H773Y (1)
EGFR P772_V774insPHV (1)
EGFR Q787Q (1)
EGFR R1052K (1)
EGFR R451C (1)
EGFR R776C + EGFR L861Q (1)
EGFR R776H (1)
EGFR R776H + EGFR C797S (1)
EGFR R776H + EGFR L861Q (1)
EGFR S464L (1)
EGFR S720I (1)
EGFR S752_I759del (1)
EGFR S768I + TP53 mutation (1)
EGFR S768_D770dup (1)
EGFR S768_D770dupSVD (1)
EGFR S768dupSVD (1)
EGFR S784F (1)
EGFR T263P (1)
EGFR T751_I759>S (1)
EGFR T790I (1)
EGFR T790M + BRAF V600E (1)
EGFR T790M + EGFR L792F (1)
EGFR T790M + EGFR L833V + EGFR H835L (1)
EGFR T790M + EGFR L861Q (1)
EGFR T790M + EGFR S768I + EGFR L858R (1)
EGFR T790M + HER-2 mutation (1)
EGFR T790M + KRAS G12V (1)
EGFR T790M + MET mutation (1)
EGFR T790M + PARP1 mutation (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR T790M + TP53 R237C (1)
EGFR T854A + EGFR T790M (1)
EGFR T858R (1)
EGFR V769A (1)
EGFR V769_770insASV (1)
EGFR V774_C775insHV (1)
EGFR V786M (1)
EGFR V802I (1)
EGFR V834L (1)
EGFR Y764_V765insHH (1)
EGFR exon 18 mutation + EGFR exon 21 mutation (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)
EGFR exon 19 deletion + EGFR T790L (1)
EGFR exon 19 deletion + TP53 exon 8 mutation (1)
EGFR exon 19 deletion + TP53 mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)
EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR exon 21 mutation + EGFR L858R (1)
EGFR mutation + ALK mutation (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
EGFR mutation + CTBP2 rs376695472 (1)
EGFR mutation + CTBP2 rs945665113 (1)
EGFR mutation + EGFR T790M + EGFR C797S (1)
EGFR mutation + FAT3 mutation (1)
EGFR mutation + GRM8 mutation (1)
EGFR mutation + HLA-DRB5 rs1071748 (1)
EGFR mutation + HLA-DRB5 rs184278615 (1)
EGFR mutation + HLA-DRB5 rs20146916 (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation + KIR3DL1 rs199822561 (1)
EGFR mutation + KIR3DL1 rs200821495 (1)
EGFR mutation + KIR3DL1 rs72629105 (1)
EGFR mutation + KIR3DL2 rs973541788 (1)
EGFR mutation + LRP1B mutation (1)
EGFR mutation + MDM4 *32C>A (1)
EGFR mutation + MET Y1003N (1)
EGFR mutation + NOTCH1 mutation (1)
EGFR mutation + RB1 mutation (1)
EGFR mutation + SMAD4 mutation (1)
EGFR mutation + TP53 exon 6 mutation (1)
EGFR mutation + TP53 exon 7 mutation (1)
EGFR mutation + UBXN11 mutation (1)
EGFR mutation + ZNF217 mutation (1)
EGFR mutation+ IDH1 R132H (1)
EGFR rearrangement (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EGFR wild-type + MET wild-type (1)
EGFR-SEPTIN14 rearrangement (1)
EGFR G729A + EGFR L858R (1)
EGFR T790M + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH2 R140W + EGFR L858R (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
MTOR L1433S + EGFR L858R + EGFR T790M (1)
AKT1 E17K + BRAF V600 (1)
BRAF 486_490 del (1)
BRAF D594N (1)
BRAF G464 (1)
BRAF G464E (1)
BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)
BRAF G466V + KIT K509Q (1)
BRAF G469R (1)
BRAF G469S (1)
BRAF G596V (1)
BRAF L505H (1)
BRAF L597K (1)
BRAF L597S (1)
BRAF N486-P490del + TP53 V157G (1)
BRAF S365L (1)
BRAF T599 (1)
BRAF V600 wild-type (1)
BRAF V600DK601del (1)
BRAF V600E + BRAF G469A + BRAF G469V (1)
BRAF V600E + BRAF K601_W604del (1)
BRAF V600E + BRAF L514V (1)
BRAF V600E + BRAF V600K (1)
BRAF V600E + KRAS G12R (1)
BRAF V600E + MSI-H/dMMR (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF V600_K601delinsE (1)
BRAF Y472C (1)
BRAF mutation + MAP2K1 mutation (1)
BRAF mutation + RAS mutation (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
BRAF mutation + TET2 mutation (1)
BRAF mutation + TP53 mutation (1)
BRAF wild-type + NRAS wild-type (1)
KRAS G12A + BRAF D549N (1)
KRAS G12V + BRAF V600E (1)
MAP2K1 V211D + BRAF mutation (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G13D + BRAF V600E (1)
RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)
ROS1 rearrangement + BRAF V600E (1)
TERT promoter mutation + BRAF V600 (1)
EGFR A839V (0)
EGFR E709A (0)
EGFR E709F (0)
EGFR G779C (0)
EGFR G873E (0)
EGFR H773L (0)
EGFR K754E (0)
EGFR L747_S752del (0)
EGFR L747_T750del (0)
EGFR L858R + EGFR G779S (0)
EGFR L858R + RBM10 Q255 (0)
EGFR R776C (0)
EGFR S765I (0)
EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)
EGFR V774M (0)
EGFR mutation + APC mutation (0)
EGFR rs4947492 (0)
MET exon 14 skipping mutation + EGFR G709T (0)
BRAF K601 (0)
BRAF L597 (0)
BRAF V600E + TERT mutation (0)
BRAF V600E + KRAS G12D (0)
BRAF V600E + MAP2K1 P124S (0)
BRAF exon 11 mutation (0)
BRAF exon 15 mutation (0)
CDKN2A mutation + BRAF V600E (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
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EGFR mutation + BRAF V600
Lung Adenocarcinoma
EGFR mutation + BRAF V600
Lung Adenocarcinoma
trametinib + osimertinib + dabrafenib
Sensitive: C4 – Case Studies
trametinib + osimertinib + dabrafenib
Sensitive
:
C4
trametinib + osimertinib + dabrafenib
Sensitive: C4 – Case Studies
trametinib + osimertinib + dabrafenib
Sensitive
:
C4
EGFR mutation + BRAF V600
Lung Adenocarcinoma
EGFR mutation + BRAF V600
Lung Adenocarcinoma
osimertinib
Resistant: C4 – Case Studies
osimertinib
Resistant
:
C4
osimertinib
Resistant: C4 – Case Studies
osimertinib
Resistant
:
C4
^
^
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