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    DRUG:

    DM005

    i
    Other names: DM005, YH013, DM-005, DM 005, YH-013, YH 013
    Company:
    Biocytogen, Doma Pharma
    Drug class:
    Topoisomerase I inhibitor, EGFR-targeted antibody-drug conjugate, c-MET-targeted antibody-drug conjugate
    Related drugs:
    4ms
    A Study of DM005 in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=136, Not yet recruiting, Doma Biopharmaceutical（Suzhou）Co., Ltd.
    New P1 trial • Metastases
    |
    DM005
    over1year
    YH013, a novel EGFR x MET bispecific antibody-drug conjugate, exhibits potent antitumor efficacy (AACR 2023)
    Moreover, in multiple patient-derived xenografts of NSCLC and pancreatic ductal adenocarcinoma (PDAC), which co-express EGFR and MET, YH013 demonstrated superior and durable efficacy that outperformed benchmark antibodies at a lower dose (3 mg/kg). Collectively, these results suggest that YH013 can be an effective treatment option for EGFR and MET co-expressing tumors and overcome MET-driven EGFR-TKI resistance to improve patient outcomes.
    Clinical
    |
    MET (MET proto-oncogene, receptor tyrosine kinase)
    |
    MET amplification • EGFR expression • MET expression • EGFR H1975 • EGFR expression + MET expression
    |
    DM005