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DRUG:

Trodelvy (sacituzumab govitecan-hziy)

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Company:

Everest Medicines, Gilead

Drug class:

Topoisomerase I inhibitor, Trop-2-targeted antibody-drug conjugate

Related drugs:

No biomarker	Urothelial Cancer	No biomarker	Urothelial Cancer	sacituzumab govitecan-hziy Sensitive: A1 - Approval sacituzumab govitecan-hziy Sensitive : A1	sacituzumab govitecan-hziy Sensitive: A1 - Approval sacituzumab govitecan-hziy Sensitive : A1
HR positive	HER2 Negative Breast Cancer	HR positive	HER2 Negative Breast Cancer	sacituzumab govitecan-hziy Sensitive: A1 - Approval sacituzumab govitecan-hziy Sensitive : A1	sacituzumab govitecan-hziy Sensitive: A1 - Approval sacituzumab govitecan-hziy Sensitive : A1
No biomarker	Triple Negative Breast Cancer	No biomarker	Triple Negative Breast Cancer	sacituzumab govitecan-hziy Sensitive: A1 - Approval sacituzumab govitecan-hziy Sensitive : A1	sacituzumab govitecan-hziy Sensitive: A1 - Approval sacituzumab govitecan-hziy Sensitive : A1
No biomarker	Bladder Cancer	No biomarker	Bladder Cancer	sacituzumab govitecan-hziy Sensitive: A2 - Guideline sacituzumab govitecan-hziy Sensitive : A2	sacituzumab govitecan-hziy Sensitive: A2 - Guideline sacituzumab govitecan-hziy Sensitive : A2
No biomarker	Non Small Cell Lung Cancer	No biomarker	Non Small Cell Lung Cancer	sacituzumab govitecan-hziy Sensitive: B - Late Trials sacituzumab govitecan-hziy Sensitive : B	sacituzumab govitecan-hziy Sensitive: B - Late Trials sacituzumab govitecan-hziy Sensitive : B
HER-2 negative	HER2 Negative Breast Cancer	HER-2 negative	HER2 Negative Breast Cancer	sacituzumab govitecan-hziy Sensitive: C2 – Inclusion Criteria sacituzumab govitecan-hziy Sensitive : C2	sacituzumab govitecan-hziy Sensitive: C2 – Inclusion Criteria sacituzumab govitecan-hziy Sensitive : C2
BRCA1 mutation	Endometrial Cancer	BRCA1 mutation	Endometrial Cancer	rucaparib + sacituzumab govitecan-hziy Sensitive: C3 – Early Trials rucaparib + sacituzumab govitecan-hziy Sensitive : C3	rucaparib + sacituzumab govitecan-hziy Sensitive: C3 – Early Trials rucaparib + sacituzumab govitecan-hziy Sensitive : C3
MSI-H/dMMR + PD-L1 expression	Triple Negative Breast Cancer	MSI-H/dMMR + PD-L1 expression	Triple Negative Breast Cancer	sacituzumab govitecan-hziy Resistant: C4 – Case Studies sacituzumab govitecan-hziy Resistant : C4	sacituzumab govitecan-hziy Resistant: C4 – Case Studies sacituzumab govitecan-hziy Resistant : C4
TROP2 overexpression	Triple Negative Breast Cancer	TROP2 overexpression	Triple Negative Breast Cancer	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D
TROP2 expression	Cervical Cancer	TROP2 expression	Cervical Cancer	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D
TROP2 overexpression	Endometrial Cancer	TROP2 overexpression	Endometrial Cancer	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D
TROP2 positive	Triple Negative Breast Cancer	TROP2 positive	Triple Negative Breast Cancer	sacituzumab govitecan-hziy + BAY 1895344 Sensitive: D – Preclinical sacituzumab govitecan-hziy + BAY 1895344 Sensitive : D	sacituzumab govitecan-hziy + BAY 1895344 Sensitive: D – Preclinical sacituzumab govitecan-hziy + BAY 1895344 Sensitive : D
HR positive	Hormone Receptor Positive Breast Cancer	HR positive	Hormone Receptor Positive Breast Cancer	sacituzumab govitecan-hziy + BAY 1895344 Sensitive: D – Preclinical sacituzumab govitecan-hziy + BAY 1895344 Sensitive : D	sacituzumab govitecan-hziy + BAY 1895344 Sensitive: D – Preclinical sacituzumab govitecan-hziy + BAY 1895344 Sensitive : D
RAB5A expression	HER2 Positive Breast Cancer	RAB5A expression	HER2 Positive Breast Cancer	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D	sacituzumab govitecan-hziy Sensitive: D – Preclinical sacituzumab govitecan-hziy Sensitive : D