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DRUG:

serclutamab talirine (ABBV-321)

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Company:

AbbVie

Drug class:

DNA replication inhibitor, EGFR-targeted antibody-drug conjugate

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PF-06647263 (0)

LR004-VC-MMAE (5)

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EGFR overexpression	Glioblastoma	EGFR overexpression	Glioblastoma	ABBV-321 Sensitive: C2 – Inclusion Criteria ABBV-321 Sensitive : C2	ABBV-321 Sensitive: C2 – Inclusion Criteria ABBV-321 Sensitive : C2
EGFR overexpression	Triple Negative Breast Cancer	EGFR overexpression	Triple Negative Breast Cancer	ABT 263 + ABBV-321 Sensitive: D – Preclinical ABT 263 + ABBV-321 Sensitive : D	ABT 263 + ABBV-321 Sensitive: D – Preclinical ABT 263 + ABBV-321 Sensitive : D
EGFR expression	Head and Neck Cancer	EGFR expression	Head and Neck Cancer	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D
EGFR expression	Lung Cancer	EGFR expression	Lung Cancer	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D
EGFR overexpression	Mesothelioma	EGFR overexpression	Mesothelioma	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D
EGFR underexpression	Colorectal Cancer	EGFR underexpression	Colorectal Cancer	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D	ABBV-321 Sensitive: D – Preclinical ABBV-321 Sensitive : D