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GENE:

TSC1 (TSC complex subunit 1)

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TSC1 deletion	Urothelial Cancer	TSC1 deletion	Urothelial Cancer	AN2025 Sensitive: C3 – Early Trials AN2025 Sensitive : C3	AN2025 Sensitive: C3 – Early Trials AN2025 Sensitive : C3
TSC1 mutation	Endometrial Cancer	TSC1 mutation	Endometrial Cancer	temsirolimus Sensitive: C3 – Early Trials temsirolimus Sensitive : C3	temsirolimus Sensitive: C3 – Early Trials temsirolimus Sensitive : C3
TSC1 mutation	Renal Cell Carcinoma	TSC1 mutation	Renal Cell Carcinoma	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3
TSC1 mutation	Renal Cell Carcinoma	TSC1 mutation	Renal Cell Carcinoma	temsirolimus Sensitive: C3 – Early Trials temsirolimus Sensitive : C3	temsirolimus Sensitive: C3 – Early Trials temsirolimus Sensitive : C3
TSC1 1907_1908del	Bladder Cancer	TSC1 1907_1908del	Bladder Cancer	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3
TSC1 mutation	Bladder Cancer	TSC1 mutation	Bladder Cancer	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3
TSC1 mutation	Renal Cell Carcinoma	TSC1 mutation	Renal Cell Carcinoma	mTOR inhibitor Sensitive: C3 – Early Trials mTOR inhibitor Sensitive : C3	mTOR inhibitor Sensitive: C3 – Early Trials mTOR inhibitor Sensitive : C3
TSC1 deletion	Renal Cell Carcinoma	TSC1 deletion	Renal Cell Carcinoma	everolimus Sensitive: C4 – Case Studies everolimus Sensitive : C4	everolimus Sensitive: C4 – Case Studies everolimus Sensitive : C4
TSC1 deletion	Renal Cell Carcinoma	TSC1 deletion	Renal Cell Carcinoma	temsirolimus Sensitive: C4 – Case Studies temsirolimus Sensitive : C4	temsirolimus Sensitive: C4 – Case Studies temsirolimus Sensitive : C4
TSC1 mutation	Hepatocellular Cancer	TSC1 mutation	Hepatocellular Cancer	everolimus Sensitive: C4 – Case Studies everolimus Sensitive : C4	everolimus Sensitive: C4 – Case Studies everolimus Sensitive : C4
PTEN mutation + TSC1 mutation	Leiomyosarcoma	PTEN mutation + TSC1 mutation	Leiomyosarcoma	CB-228 Sensitive: C4 – Case Studies CB-228 Sensitive : C4	CB-228 Sensitive: C4 – Case Studies CB-228 Sensitive : C4