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BIOMARKER:

EML4-ALK variant 3 + TP53 mutation

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Entrez ID:

238; 7157; 27436

Related biomarkers:

‹

TP53 mutation + Chr del(17p) (14)

FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

BRCA wild-type + TP53 mutation (3)

TP53 mutation + Chr del(11q) (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

HR positive + TP53 mutation (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TMB-H + ALK rearrangement (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

CD74-ROS1 fusion + TP53 mutation (1)

Chr del(5q) + TP53 expression (1)

Chr t(11;14) + TP53 mutation (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + TP53 mutation (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + TP53 expression (1)

FAT1 mutation + TP53 wild-type (1)

FLT3 wild-type + TP53 mutation (1)

FLT3-ITD mutation + MLL fusion + TP53 mutation (1)

GNA13 deletion + TP53 mutation (1)

HER-2 positive + TP53 mutation (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

KRAS G12D + TP53 deletion (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDH elevation + TP53 mutation (1)

LRP1B mutation + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MSI-H/dMMR + TP53 mutation (1)

MSLN overexpression + TP53 mutation (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

ROS1 fusion + TP53 mutation (1)

ROS1-CD74 fusion + TP53 K139N (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMEM87A-RASGRF1 fusion + TP53 R273H (1)

TP53 R280K + BRCA wild-type (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 deletion + RB1 deletion + CTSK expression (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + FGFR2 fusion (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TP53 wild-type + ER positive (1)

PD-L1 underexpression + ALK wild-type (0)

FGFR2 K660N + TP53 deletion (0)

TP53 mutation + Chr del(17p) (14)

FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

BRCA wild-type + TP53 mutation (3)

TP53 mutation + Chr del(11q) (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

HR positive + TP53 mutation (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TMB-H + ALK rearrangement (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

CD74-ROS1 fusion + TP53 mutation (1)

Chr del(5q) + TP53 expression (1)

Chr t(11;14) + TP53 mutation (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + TP53 mutation (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + TP53 expression (1)

FAT1 mutation + TP53 wild-type (1)

FLT3 wild-type + TP53 mutation (1)

FLT3-ITD mutation + MLL fusion + TP53 mutation (1)

GNA13 deletion + TP53 mutation (1)

HER-2 positive + TP53 mutation (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

KRAS G12D + TP53 deletion (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDH elevation + TP53 mutation (1)

LRP1B mutation + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MSI-H/dMMR + TP53 mutation (1)

MSLN overexpression + TP53 mutation (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

ROS1 fusion + TP53 mutation (1)

ROS1-CD74 fusion + TP53 K139N (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMEM87A-RASGRF1 fusion + TP53 R273H (1)

TP53 R280K + BRCA wild-type (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 deletion + RB1 deletion + CTSK expression (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + FGFR2 fusion (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TP53 wild-type + ER positive (1)

PD-L1 underexpression + ALK wild-type (0)

FGFR2 K660N + TP53 deletion (0)

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EML4-ALK variant 3 + TP53 mutation	Non Small Cell Lung Cancer	EML4-ALK variant 3 + TP53 mutation	Non Small Cell Lung Cancer	crizotinib Resistant: C3 – Early Trials crizotinib Resistant : C3	crizotinib Resistant: C3 – Early Trials crizotinib Resistant : C3
EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	alectinib Resistant: C4 – Case Studies alectinib Resistant : C4	alectinib Resistant: C4 – Case Studies alectinib Resistant : C4
EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	brigatinib Resistant: C4 – Case Studies brigatinib Resistant : C4	brigatinib Resistant: C4 – Case Studies brigatinib Resistant : C4
EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	lorlatinib Resistant: D – Preclinical lorlatinib Resistant : D	lorlatinib Resistant: D – Preclinical lorlatinib Resistant : D
EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	EML4-ALK variant 3 + TP53 mutation	Lung Adenocarcinoma	crizotinib Sensitive: D – Preclinical crizotinib Sensitive : D	crizotinib Sensitive: D – Preclinical crizotinib Sensitive : D