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BIOMARKER:

DNMT3A mutation + ASXL1 mutation + NRAS mutation

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Entrez ID:

4893; 1788; 171023

Related biomarkers:

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NRAS mutation (125)

DNMT3A mutation (28)

ASXL1 mutation (20)

RAS wild-type (17)

NRAS wild-type (10)

NRAS mutation + BRAF mutation (4)

DNMT3A mutation + FLT3-ITD mutation (4)

FLT3 mutation + NRAS mutation (3)

NRAS Q61K + BRAF V600E (3)

NRAS exon 2 mutation (3)

NRAS exon 4 mutation (3)

DNMT3A R882H (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

EGFR mutation + NRAS Q61K (2)

NRAS G12C + BRAF mutation (2)

NRAS exon 3 mutation (2)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

ARAF mutation + NRAS mutation (1)

ASXL1 mutation + NRAS mutation (1)

BRAF wild-type + NRAS wild-type (1)

DNMT3A mutation + NRAS mutation (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

HRAS Q61L + NRAS Q61K (1)

IDH2 mutation + NRAS mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

NRAS G115Efs*46 (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

NRAS mutation + U2AF1 mutation (1)

SETBP1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + NRAS mutation (1)

DNMT3A R882 (1)

DNMT3A mutation + ASXL1 mutation (1)

DNMT3A mutation + IDH mutation (1)

DNMT3A mutation + SF3B1 mutation (1)

DNMT3A rs11681717 (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

KRAS G12D + DNMT3A C559fsX (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

ASXL1 G646Wfs*12 (1)

ASXL1 Y588X (1)

ASXL1 mutation + ATM mutation (1)

FLT3-ITD mutation + ASXL1 mutation (1)

TET2 mutation + DNMT3A mutation (0)

ASXL1 G710X (0)

NRAS mutation (125)

DNMT3A mutation (28)

ASXL1 mutation (20)

RAS wild-type (17)

NRAS wild-type (10)

NRAS mutation + BRAF mutation (4)

DNMT3A mutation + FLT3-ITD mutation (4)

FLT3 mutation + NRAS mutation (3)

NRAS Q61K + BRAF V600E (3)

NRAS exon 2 mutation (3)

NRAS exon 4 mutation (3)

DNMT3A R882H (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

EGFR mutation + NRAS Q61K (2)

NRAS G12C + BRAF mutation (2)

NRAS exon 3 mutation (2)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

ARAF mutation + NRAS mutation (1)

ASXL1 mutation + NRAS mutation (1)

BRAF wild-type + NRAS wild-type (1)

DNMT3A mutation + NRAS mutation (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

HRAS Q61L + NRAS Q61K (1)

IDH2 mutation + NRAS mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

NRAS G115Efs*46 (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

NRAS mutation + U2AF1 mutation (1)

SETBP1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + NRAS mutation (1)

DNMT3A R882 (1)

DNMT3A mutation + ASXL1 mutation (1)

DNMT3A mutation + IDH mutation (1)

DNMT3A mutation + SF3B1 mutation (1)

DNMT3A rs11681717 (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

KRAS G12D + DNMT3A C559fsX (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

ASXL1 G646Wfs*12 (1)

ASXL1 Y588X (1)

ASXL1 mutation + ATM mutation (1)

FLT3-ITD mutation + ASXL1 mutation (1)

TET2 mutation + DNMT3A mutation (0)

ASXL1 G710X (0)

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DNMT3A mutation + ASXL1 mutation + NRAS mutation

Acute Myelogenous Leukemia

cytarabine + idarubicin

Resistant: C3 – Early Trials

cytarabine + idarubicin

cytarabine + idarubicin

Resistant: C3 – Early Trials

cytarabine + idarubicin