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BIOMARKER:

DNMT3A mutation

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Other names: DNMT3A, DNA Methyltransferase 3 Alpha, DNA (Cytosine-5-)-Methyltransferase 3 Alpha, DNA (Cytosine-5)-Methyltransferase 3A, DNA MTase HsaIIIA, DNA Cytosine Methyltransferase 3A2, DNA Methyltransferase HsaIIIA, DNMT3A2, Dnmt3a
Entrez ID:
Related biomarkers:
DNMT3A mutation
AML
azacitidine
Resistant: B - Late Trials
DNMT3A mutation
AML
venetoclax + midostaurin
Resistant: C3 – Early Trials
DNMT3A mutation
MDS
pembrolizumab
Sensitive: C3 – Early Trials
DNMT3A mutation
AML
cytarabine
Resistant: C3 – Early Trials
DNMT3A mutation
AML
venetoclax
Sensitive: C3 – Early Trials
DNMT3A mutation
AML
venetoclax + gilteritinib
Resistant: C3 – Early Trials
DNMT3A mutation
AML
venetoclax + sorafenib
Resistant: C3 – Early Trials
DNMT3A mutation
MDS
azacitidine
Resistant: C3 – Early Trials
DNMT3A mutation
MDS
decitabine
Resistant: C3 – Early Trials
DNMT3A mutation
AML
quizartinib
Sensitive: C3 – Early Trials
DNMT3A mutation
CML
YD312
Resistant: C3 – Early Trials
DNMT3A mutation
AML
decitabine/cedazuridine
Sensitive: C3 – Early Trials
DNMT3A mutation
CRC
sintilimab + fruquintinib
Resistant: C3 – Early Trials
DNMT3A mutation
T Cell Non-Hodgkin Lymphoma
lenalidomide
Resistant: C3 – Early Trials
DNMT3A mutation
NSCLC
PD-L1 inhibitor
Sensitive: C3 – Early Trials
DNMT3A mutation
AML
EPZ-5676
Sensitive: D – Preclinical
DNMT3A mutation
AML
ABBV-744
Sensitive: D – Preclinical