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BIOMARKER:
HER-2 amplification + RAS wild-type + BRAF wild-type
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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Entrez ID:
2064
;
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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VERI cancer hierarchy
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HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
trastuzumab + pertuzumab
Sensitive: A2 - Guideline
trastuzumab + pertuzumab
Sensitive
:
A2
trastuzumab + pertuzumab
Sensitive: A2 - Guideline
trastuzumab + pertuzumab
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
trastuzumab + pertuzumab
Sensitive: A2 - Guideline
trastuzumab + pertuzumab
Sensitive
:
A2
trastuzumab + pertuzumab
Sensitive: A2 - Guideline
trastuzumab + pertuzumab
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
trastuzumab + tucatinib
Sensitive: A2 - Guideline
trastuzumab + tucatinib
Sensitive
:
A2
trastuzumab + tucatinib
Sensitive: A2 - Guideline
trastuzumab + tucatinib
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
trastuzumab + tucatinib
Sensitive: A2 - Guideline
trastuzumab + tucatinib
Sensitive
:
A2
trastuzumab + tucatinib
Sensitive: A2 - Guideline
trastuzumab + tucatinib
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Rectal Cancer
fam-trastuzumab deruxtecan-nxki
Sensitive: A2 - Guideline
fam-trastuzumab deruxtecan-nxki
Sensitive
:
A2
fam-trastuzumab deruxtecan-nxki
Sensitive: A2 - Guideline
fam-trastuzumab deruxtecan-nxki
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Colon Cancer
fam-trastuzumab deruxtecan-nxki
Sensitive: A2 - Guideline
fam-trastuzumab deruxtecan-nxki
Sensitive
:
A2
fam-trastuzumab deruxtecan-nxki
Sensitive: A2 - Guideline
fam-trastuzumab deruxtecan-nxki
Sensitive
:
A2
HER-2 amplification + RAS wild-type + BRAF wild-type
Colorectal Cancer
HER-2 amplification + RAS wild-type + BRAF wild-type
Colorectal Cancer
pertuzumab + ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
pertuzumab + ado-trastuzumab emtansine
Sensitive
:
C3
pertuzumab + ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
pertuzumab + ado-trastuzumab emtansine
Sensitive
:
C3
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