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BIOMARKER:
BRAF V600
i
Other names:
BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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Entrez ID:
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BRAF V600E (255)
BRAF mutation (129)
BRAF V600K (25)
BRAF wild-type (25)
BRAF G469V (7)
BRAF K601E (7)
RAS wild-type + BRAF wild-type (7)
BRAF D594G (6)
BRAF V600E + RNF43 mutation (6)
EGFR mutation + BRAF V600E (6)
BRAF G466V (4)
BRAF V600E + PIK3CA mutation (4)
BRAF V600G (4)
NRAS mutation + BRAF mutation (4)
BRAF D549G (3)
BRAF G469A (3)
BRAF G469E (3)
BRAF L597Q (3)
BRAF L597R (3)
BRAF T1799A (3)
BRAF V595E (3)
BRAF V600E + TERT mutation (3)
BRAF V600R (3)
BRAF delNVTAP (3)
NRAS Q61K + BRAF V600E (3)
TERT mutation + BRAF V600E (3)
BRAF G466A (2)
BRAF L485W (2)
BRAF V600D (2)
BRAF V600E + MAP2K1 I111S (2)
BRAF V600M (2)
BRAF mutation + MEK1 P124L (2)
BRAF mutation + NF1 mutation (2)
BRAF rearrangement (2)
EGFR mutation + BRAF V600 (2)
IDH1 wild-type + BRAF mutation (2)
KRAS G13D + BRAF mutation (2)
MYD88 L265P + BRAF V600E (2)
NRAS G12C + BRAF mutation (2)
AKT1 E17K + BRAF V600 (1)
BRAF 486_490 del (1)
BRAF D594N (1)
BRAF G464 (1)
BRAF G464E (1)
BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)
BRAF G466V + KIT K509Q (1)
BRAF G469R (1)
BRAF G469S (1)
BRAF G596V (1)
BRAF L505H (1)
BRAF L597K (1)
BRAF L597S (1)
BRAF N486-P490del + TP53 V157G (1)
BRAF S365L (1)
BRAF T599 (1)
BRAF V600 wild-type (1)
BRAF V600DK601del (1)
BRAF V600E + BRAF G469A + BRAF G469V (1)
BRAF V600E + BRAF K601_W604del (1)
BRAF V600E + BRAF L514V (1)
BRAF V600E + BRAF V600K (1)
BRAF V600E + KRAS G12R (1)
BRAF V600E + MSI-H/dMMR (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF V600_K601delinsE (1)
BRAF Y472C (1)
BRAF mutation + EGFR mutation (1)
BRAF mutation + MAP2K1 mutation (1)
BRAF mutation + RAS mutation (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
BRAF mutation + TET2 mutation (1)
BRAF mutation + TP53 mutation (1)
BRAF wild-type + NRAS wild-type (1)
EGFR T790M + BRAF V600E (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12V + BRAF V600E (1)
MAP2K1 V211D + BRAF mutation (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G13D + BRAF V600E (1)
RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)
ROS1 rearrangement + BRAF V600E (1)
TERT promoter mutation + BRAF V600 (1)
BRAF K601 (0)
BRAF L597 (0)
BRAF V600E + TERT mutation (0)
BRAF V600E + KRAS G12D (0)
BRAF V600E + MAP2K1 P124S (0)
BRAF exon 11 mutation (0)
BRAF exon 15 mutation (0)
CDKN2A mutation + BRAF V600E (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
BRAF V600E (255)
BRAF mutation (129)
BRAF V600K (25)
BRAF wild-type (25)
BRAF G469V (7)
BRAF K601E (7)
RAS wild-type + BRAF wild-type (7)
BRAF D594G (6)
BRAF V600E + RNF43 mutation (6)
EGFR mutation + BRAF V600E (6)
BRAF G466V (4)
BRAF V600E + PIK3CA mutation (4)
BRAF V600G (4)
NRAS mutation + BRAF mutation (4)
BRAF D549G (3)
BRAF G469A (3)
BRAF G469E (3)
BRAF L597Q (3)
BRAF L597R (3)
BRAF T1799A (3)
BRAF V595E (3)
BRAF V600E + TERT mutation (3)
BRAF V600R (3)
BRAF delNVTAP (3)
NRAS Q61K + BRAF V600E (3)
TERT mutation + BRAF V600E (3)
BRAF G466A (2)
BRAF L485W (2)
BRAF V600D (2)
BRAF V600E + MAP2K1 I111S (2)
BRAF V600M (2)
BRAF mutation + MEK1 P124L (2)
BRAF mutation + NF1 mutation (2)
BRAF rearrangement (2)
EGFR mutation + BRAF V600 (2)
IDH1 wild-type + BRAF mutation (2)
KRAS G13D + BRAF mutation (2)
MYD88 L265P + BRAF V600E (2)
NRAS G12C + BRAF mutation (2)
AKT1 E17K + BRAF V600 (1)
BRAF 486_490 del (1)
BRAF D594N (1)
BRAF G464 (1)
BRAF G464E (1)
BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)
BRAF G466V + KIT K509Q (1)
BRAF G469R (1)
BRAF G469S (1)
BRAF G596V (1)
BRAF L505H (1)
BRAF L597K (1)
BRAF L597S (1)
BRAF N486-P490del + TP53 V157G (1)
BRAF S365L (1)
BRAF T599 (1)
BRAF V600 wild-type (1)
BRAF V600DK601del (1)
BRAF V600E + BRAF G469A + BRAF G469V (1)
BRAF V600E + BRAF K601_W604del (1)
BRAF V600E + BRAF L514V (1)
BRAF V600E + BRAF V600K (1)
BRAF V600E + KRAS G12R (1)
BRAF V600E + MSI-H/dMMR (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF V600_K601delinsE (1)
BRAF Y472C (1)
BRAF mutation + EGFR mutation (1)
BRAF mutation + MAP2K1 mutation (1)
BRAF mutation + RAS mutation (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
BRAF mutation + TET2 mutation (1)
BRAF mutation + TP53 mutation (1)
BRAF wild-type + NRAS wild-type (1)
EGFR T790M + BRAF V600E (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12V + BRAF V600E (1)
MAP2K1 V211D + BRAF mutation (1)
NRAS G12C + BRAF V600E + BRAF V600D (1)
NRAS G13D + BRAF V600E (1)
RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)
ROS1 rearrangement + BRAF V600E (1)
TERT promoter mutation + BRAF V600 (1)
BRAF K601 (0)
BRAF L597 (0)
BRAF V600E + TERT mutation (0)
BRAF V600E + KRAS G12D (0)
BRAF V600E + MAP2K1 P124S (0)
BRAF exon 11 mutation (0)
BRAF exon 15 mutation (0)
CDKN2A mutation + BRAF V600E (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
›
Related tests:
FoundationOne® CDx (110)
FoundationOne® CDx (110)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
BRAF V600
Melanoma
BRAF V600
Melanoma
atezolizumab + vemurafenib + cobimetinib
Sensitive: A1 - Approval
atezolizumab + vemurafenib + cobimetinib
Sensitive
:
A1
atezolizumab + vemurafenib + cobimetinib
Sensitive: A1 - Approval
atezolizumab + vemurafenib + cobimetinib
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
binimetinib + encorafenib
Sensitive: A1 - Approval
binimetinib + encorafenib
Sensitive
:
A1
binimetinib + encorafenib
Sensitive: A1 - Approval
binimetinib + encorafenib
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
vemurafenib + cobimetinib
Sensitive: A1 - Approval
vemurafenib + cobimetinib
Sensitive
:
A1
vemurafenib + cobimetinib
Sensitive: A1 - Approval
vemurafenib + cobimetinib
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
dabrafenib
Sensitive: A1 - Approval
dabrafenib
Sensitive
:
A1
dabrafenib
Sensitive: A1 - Approval
dabrafenib
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
trametinib + dabrafenib
Sensitive: A1 - Approval
trametinib + dabrafenib
Sensitive
:
A1
trametinib + dabrafenib
Sensitive: A1 - Approval
trametinib + dabrafenib
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
trametinib
Sensitive: A1 - Approval
trametinib
Sensitive
:
A1
trametinib
Sensitive: A1 - Approval
trametinib
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
vemurafenib
Sensitive: A1 - Approval
vemurafenib
Sensitive
:
A1
vemurafenib
Sensitive: A1 - Approval
vemurafenib
Sensitive
:
A1
BRAF V600
Non Small Cell Lung Cancer
BRAF V600
Non Small Cell Lung Cancer
trametinib + dabrafenib
Sensitive: A1 - Approval
trametinib + dabrafenib
Sensitive
:
A1
trametinib + dabrafenib
Sensitive: A1 - Approval
trametinib + dabrafenib
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
BRAF V600
Melanoma
BRAF V600
Melanoma
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
BRAF V600
Glioma
BRAF V600
Glioma
tovorafenib
Sensitive: A1 - Approval
tovorafenib
Sensitive
:
A1
tovorafenib
Sensitive: A1 - Approval
tovorafenib
Sensitive
:
A1
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
trametinib
Resistant: A2 - Guideline
trametinib
Resistant
:
A2
trametinib
Resistant: A2 - Guideline
trametinib
Resistant
:
A2
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
atezolizumab + vemurafenib + cobimetinib
Sensitive: A2 - Guideline
atezolizumab + vemurafenib + cobimetinib
Sensitive
:
A2
atezolizumab + vemurafenib + cobimetinib
Sensitive: A2 - Guideline
atezolizumab + vemurafenib + cobimetinib
Sensitive
:
A2
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
vemurafenib + cobimetinib
Sensitive: A2 - Guideline
vemurafenib + cobimetinib
Sensitive
:
A2
vemurafenib + cobimetinib
Sensitive: A2 - Guideline
vemurafenib + cobimetinib
Sensitive
:
A2
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
binimetinib + encorafenib
Sensitive: A2 - Guideline
binimetinib + encorafenib
Sensitive
:
A2
binimetinib + encorafenib
Sensitive: A2 - Guideline
binimetinib + encorafenib
Sensitive
:
A2
BRAF V600
Melanoma
BRAF V600
Melanoma
BRAF inhibitor + MEK inhibitor
Sensitive: A2 - Guideline
BRAF inhibitor + MEK inhibitor
Sensitive
:
A2
BRAF inhibitor + MEK inhibitor
Sensitive: A2 - Guideline
BRAF inhibitor + MEK inhibitor
Sensitive
:
A2
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
trametinib + dabrafenib
Sensitive: A2 - Guideline
trametinib + dabrafenib
Sensitive
:
A2
trametinib + dabrafenib
Sensitive: A2 - Guideline
trametinib + dabrafenib
Sensitive
:
A2
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
pembrolizumab + dabrafenib
Sensitive: A2 - Guideline
pembrolizumab + dabrafenib
Sensitive
:
A2
pembrolizumab + dabrafenib
Sensitive: A2 - Guideline
pembrolizumab + dabrafenib
Sensitive
:
A2
BRAF V600
Cutaneous Melanoma
BRAF V600
Cutaneous Melanoma
pembrolizumab + trametinib
Sensitive: A2 - Guideline
pembrolizumab + trametinib
Sensitive
:
A2
pembrolizumab + trametinib
Sensitive: A2 - Guideline
pembrolizumab + trametinib
Sensitive
:
A2
BRAF V600
Rectal Cancer
BRAF V600
Rectal Cancer
cetuximab + encorafenib
Sensitive: A2 - Guideline
cetuximab + encorafenib
Sensitive
:
A2
cetuximab + encorafenib
Sensitive: A2 - Guideline
cetuximab + encorafenib
Sensitive
:
A2
BRAF V600
Rectal Cancer
BRAF V600
Rectal Cancer
panitumumab + encorafenib
Sensitive: A2 - Guideline
panitumumab + encorafenib
Sensitive
:
A2
panitumumab + encorafenib
Sensitive: A2 - Guideline
panitumumab + encorafenib
Sensitive
:
A2
BRAF V600
Melanoma
BRAF V600
Melanoma
trametinib + dabrafenib + PDR001
Sensitive: B - Late Trials
trametinib + dabrafenib + PDR001
Sensitive
:
B
trametinib + dabrafenib + PDR001
Sensitive: B - Late Trials
trametinib + dabrafenib + PDR001
Sensitive
:
B
BRAF V600
Melanoma
BRAF V600
Melanoma
nivolumab + ipilimumab
Sensitive: B - Late Trials
nivolumab + ipilimumab
Sensitive
:
B
nivolumab + ipilimumab
Sensitive: B - Late Trials
nivolumab + ipilimumab
Sensitive
:
B
BRAF V600
Melanoma
BRAF V600
Melanoma
PD1 inhibitor
Sensitive: B - Late Trials
PD1 inhibitor
Sensitive
:
B
PD1 inhibitor
Sensitive: B - Late Trials
PD1 inhibitor
Sensitive
:
B
BRAF V600
Thyroid Gland Carcinoma
BRAF V600
Thyroid Gland Carcinoma
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
BRAF V600
Ocular Melanoma
BRAF V600
Ocular Melanoma
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
BRAF V600
Ocular Melanoma
BRAF V600
Ocular Melanoma
trametinib + dabrafenib
Sensitive: C1 - Off-label
trametinib + dabrafenib
Sensitive
:
C1
trametinib + dabrafenib
Sensitive: C1 - Off-label
trametinib + dabrafenib
Sensitive
:
C1
BRAF V600
Multiple Myeloma
BRAF V600
Multiple Myeloma
binimetinib + encorafenib
Sensitive: C1 - Off-label
binimetinib + encorafenib
Sensitive
:
C1
binimetinib + encorafenib
Sensitive: C1 - Off-label
binimetinib + encorafenib
Sensitive
:
C1
BRAF V600
Colorectal Cancer
BRAF V600
Colorectal Cancer
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
BRAF V600
Cholangiocarcinoma
BRAF V600
Cholangiocarcinoma
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
BRAF V600
Ganglioglioma
BRAF V600
Ganglioglioma
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
vemurafenib
Sensitive: C1 - Off-label
vemurafenib
Sensitive
:
C1
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