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BIOMARKER:
ALK positive
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK rearrangement (43)
ALK mutation (20)
ALK wild-type (18)
STRN-ALK rearrangement (10)
ALK translocation (9)
ALK F1174L (7)
ALK G1202R (7)
EGFR wild-type + ALK wild-type (7)
ALK C1156Y (6)
ALK A348D (5)
ALK F856S (5)
EML4-ALK rearrangement (5)
ALK G1202del (4)
ALK G1269A (4)
ALK I1171N (4)
ALK I1171T (4)
ALK rearrangement + TP53 mutation (4)
ALK F1174C (3)
ALK F1174V (3)
ALK F1245C (3)
ALK G1202K (3)
ALK I1171 (3)
ALK L1196M (3)
ALK R1275Q (3)
TYRO3 mutation + ALK mutation (3)
ALK C1156Y + ALK I1171T (2)
ALK C1156Y + ALK L1198F (2)
ALK E1210K (2)
ALK F1174L + ALK G1202R (2)
ALK I1171S (2)
ALK L1152R (2)
ALK L1198F (2)
ALK S1206Y (2)
ALK V1180L (2)
ALK V3a (2)
ALK V3b (2)
DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)
ALK C1156F (1)
ALK C1156Y + ALK G1202R (1)
ALK D1091N (1)
ALK D1203N (1)
ALK E1129V (1)
ALK F1174I (1)
ALK G1123S (1)
ALK G1128A (1)
ALK G1202L (1)
ALK G1202R + ALK F1174L + ALK T1151M (1)
ALK I1268L (1)
ALK L1152R + EGFR mutation (1)
ALK L1152V (1)
ALK L1196M + ALK C1156Y (1)
ALK L1196M + ALK G1202R (1)
ALK L1196M + ALK L1198F (1)
ALK L1198F + ALK G1202R (1)
ALK R1192P (1)
ALK R1209Q (1)
ALK R1231W (1)
ALK R214H (1)
ALK S1157F (1)
ALK T1151M (1)
ALK T1151R (1)
ALK TKD mutation (1)
ALK rearrangement + ALK L1196M + TP53 mutation (1)
ALK rearrangement + ALK R1275Q + TP53 mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + HER-2 mutation (1)
ALK rearrangement + KRAS mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
ALK rearrangement + TP53 wild-type (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR mutation + ALK mutation (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EML4-ALK I1171N + EML4-ALK L1196M (1)
EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)
LMO7-ALK rearrangement (1)
PLEKHH2-ALK rearrangement (1)
RMST-ALK rearrangement (1)
TP53 G245S + ALK rearrangement (1)
ALK mutation + TP53 mutation (0)
ALK rearrangement (43)
ALK mutation (20)
ALK wild-type (18)
STRN-ALK rearrangement (10)
ALK translocation (9)
ALK F1174L (7)
ALK G1202R (7)
EGFR wild-type + ALK wild-type (7)
ALK C1156Y (6)
ALK A348D (5)
ALK F856S (5)
EML4-ALK rearrangement (5)
ALK G1202del (4)
ALK G1269A (4)
ALK I1171N (4)
ALK I1171T (4)
ALK rearrangement + TP53 mutation (4)
ALK F1174C (3)
ALK F1174V (3)
ALK F1245C (3)
ALK G1202K (3)
ALK I1171 (3)
ALK L1196M (3)
ALK R1275Q (3)
TYRO3 mutation + ALK mutation (3)
ALK C1156Y + ALK I1171T (2)
ALK C1156Y + ALK L1198F (2)
ALK E1210K (2)
ALK F1174L + ALK G1202R (2)
ALK I1171S (2)
ALK L1152R (2)
ALK L1198F (2)
ALK S1206Y (2)
ALK V1180L (2)
ALK V3a (2)
ALK V3b (2)
DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)
ALK C1156F (1)
ALK C1156Y + ALK G1202R (1)
ALK D1091N (1)
ALK D1203N (1)
ALK E1129V (1)
ALK F1174I (1)
ALK G1123S (1)
ALK G1128A (1)
ALK G1202L (1)
ALK G1202R + ALK F1174L + ALK T1151M (1)
ALK I1268L (1)
ALK L1152R + EGFR mutation (1)
ALK L1152V (1)
ALK L1196M + ALK C1156Y (1)
ALK L1196M + ALK G1202R (1)
ALK L1196M + ALK L1198F (1)
ALK L1198F + ALK G1202R (1)
ALK R1192P (1)
ALK R1209Q (1)
ALK R1231W (1)
ALK R214H (1)
ALK S1157F (1)
ALK T1151M (1)
ALK T1151R (1)
ALK TKD mutation (1)
ALK rearrangement + ALK L1196M + TP53 mutation (1)
ALK rearrangement + ALK R1275Q + TP53 mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + HER-2 mutation (1)
ALK rearrangement + KRAS mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
ALK rearrangement + TP53 wild-type (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR mutation + ALK mutation (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EML4-ALK I1171N + EML4-ALK L1196M (1)
EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)
LMO7-ALK rearrangement (1)
PLEKHH2-ALK rearrangement (1)
RMST-ALK rearrangement (1)
TP53 G245S + ALK rearrangement (1)
ALK mutation + TP53 mutation (0)
›
Related tests:
VENTANA ALK (D5F3) CDx Assay (13)
VENTANA ALK (D5F3) CDx Assay (13)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
lorlatinib
Sensitive: A1 - Approval
lorlatinib
Sensitive
:
A1
lorlatinib
Sensitive: A1 - Approval
lorlatinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
alectinib
Sensitive: A1 - Approval
alectinib
Sensitive
:
A1
alectinib
Sensitive: A1 - Approval
alectinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
brigatinib
Sensitive: A1 - Approval
brigatinib
Sensitive
:
A1
brigatinib
Sensitive: A1 - Approval
brigatinib
Sensitive
:
A1
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
ensartinib
Sensitive: A1 - Approval
ensartinib
Sensitive
:
A1
ensartinib
Sensitive: A1 - Approval
ensartinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
bevacizumab + atezolizumab
Sensitive: A1 - Approval
bevacizumab + atezolizumab
Sensitive
:
A1
bevacizumab + atezolizumab
Sensitive: A1 - Approval
bevacizumab + atezolizumab
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
ceritinib
Sensitive: A1 - Approval
ceritinib
Sensitive
:
A1
ceritinib
Sensitive: A1 - Approval
ceritinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
atezolizumab
Sensitive: A1 - Approval
atezolizumab
Sensitive
:
A1
atezolizumab
Sensitive: A1 - Approval
atezolizumab
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
iruplinalkib
Sensitive: A1 - Approval
iruplinalkib
Sensitive
:
A1
iruplinalkib
Sensitive: A1 - Approval
iruplinalkib
Sensitive
:
A1
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
envonalkib
Sensitive: B - Late Trials
envonalkib
Sensitive
:
B
envonalkib
Sensitive: B - Late Trials
envonalkib
Sensitive
:
B
ALK positive
T Cell Non-Hodgkin Lymphoma
ALK positive
T Cell Non-Hodgkin Lymphoma
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
ALK positive
Lymphoma
ALK positive
Lymphoma
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
NVL-655
Sensitive: B - Late Trials
NVL-655
Sensitive
:
B
NVL-655
Sensitive: B - Late Trials
NVL-655
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ensartinib
Sensitive: C1 - Off-label
ensartinib
Sensitive
:
C1
ensartinib
Sensitive: C1 - Off-label
ensartinib
Sensitive
:
C1
ALK positive
Lung Adenocarcinoma
ALK positive
Lung Adenocarcinoma
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Non-Small Cell Squamous Cancer
ALK positive
Lung Non-Small Cell Squamous Cancer
brigatinib
Sensitive: C1 - Off-label
brigatinib
Sensitive
:
C1
brigatinib
Sensitive: C1 - Off-label
brigatinib
Sensitive
:
C1
ALK positive
Neuroendocrine Tumor
ALK positive
Neuroendocrine Tumor
alectinib
Sensitive: C1 - Off-label
alectinib
Sensitive
:
C1
alectinib
Sensitive: C1 - Off-label
alectinib
Sensitive
:
C1
ALK positive
Neuroblastoma
ALK positive
Neuroblastoma
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Cancer
ALK positive
Lung Cancer
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Adenocarcinoma
ALK positive
Lung Adenocarcinoma
ceritinib
Sensitive: C1 - Off-label
ceritinib
Sensitive
:
C1
ceritinib
Sensitive: C1 - Off-label
ceritinib
Sensitive
:
C1
ALK positive
T Cell Non-Hodgkin Lymphoma
ALK positive
T Cell Non-Hodgkin Lymphoma
crizotinib
Sensitive: C1 - Off-label
crizotinib
Sensitive
:
C1
crizotinib
Sensitive: C1 - Off-label
crizotinib
Sensitive
:
C1
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