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BIOMARKER:
ALK positive
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Related tests:
VENTANA ALK (D5F3) CDx Assay (13)
VENTANA ALK (D5F3) CDx Assay (13)
Associations
News
Trials
VERI cancer hierarchy
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ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
lorlatinib
Sensitive: A1 - Approval
lorlatinib
Sensitive
:
A1
lorlatinib
Sensitive: A1 - Approval
lorlatinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
alectinib
Sensitive: A1 - Approval
alectinib
Sensitive
:
A1
alectinib
Sensitive: A1 - Approval
alectinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
brigatinib
Sensitive: A1 - Approval
brigatinib
Sensitive
:
A1
brigatinib
Sensitive: A1 - Approval
brigatinib
Sensitive
:
A1
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
ensartinib
Sensitive: A1 - Approval
ensartinib
Sensitive
:
A1
ensartinib
Sensitive: A1 - Approval
ensartinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
bevacizumab + atezolizumab
Sensitive: A1 - Approval
bevacizumab + atezolizumab
Sensitive
:
A1
bevacizumab + atezolizumab
Sensitive: A1 - Approval
bevacizumab + atezolizumab
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
ceritinib
Sensitive: A1 - Approval
ceritinib
Sensitive
:
A1
ceritinib
Sensitive: A1 - Approval
ceritinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
atezolizumab
Sensitive: A1 - Approval
atezolizumab
Sensitive
:
A1
atezolizumab
Sensitive: A1 - Approval
atezolizumab
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
iruplinalkib
Sensitive: A1 - Approval
iruplinalkib
Sensitive
:
A1
iruplinalkib
Sensitive: A1 - Approval
iruplinalkib
Sensitive
:
A1
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
envonalkib
Sensitive: B - Late Trials
envonalkib
Sensitive
:
B
envonalkib
Sensitive: B - Late Trials
envonalkib
Sensitive
:
B
ALK positive
T Cell Non-Hodgkin Lymphoma
ALK positive
T Cell Non-Hodgkin Lymphoma
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
ALK positive
Lymphoma
ALK positive
Lymphoma
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
NVL-655
Sensitive: B - Late Trials
NVL-655
Sensitive
:
B
NVL-655
Sensitive: B - Late Trials
NVL-655
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ensartinib
Sensitive: C1 - Off-label
ensartinib
Sensitive
:
C1
ensartinib
Sensitive: C1 - Off-label
ensartinib
Sensitive
:
C1
ALK positive
Lung Adenocarcinoma
ALK positive
Lung Adenocarcinoma
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Non-Small Cell Squamous Cancer
ALK positive
Lung Non-Small Cell Squamous Cancer
brigatinib
Sensitive: C1 - Off-label
brigatinib
Sensitive
:
C1
brigatinib
Sensitive: C1 - Off-label
brigatinib
Sensitive
:
C1
ALK positive
Neuroendocrine Tumor
ALK positive
Neuroendocrine Tumor
alectinib
Sensitive: C1 - Off-label
alectinib
Sensitive
:
C1
alectinib
Sensitive: C1 - Off-label
alectinib
Sensitive
:
C1
ALK positive
Neuroblastoma
ALK positive
Neuroblastoma
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Cancer
ALK positive
Lung Cancer
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Adenocarcinoma
ALK positive
Lung Adenocarcinoma
ceritinib
Sensitive: C1 - Off-label
ceritinib
Sensitive
:
C1
ceritinib
Sensitive: C1 - Off-label
ceritinib
Sensitive
:
C1
ALK positive
T Cell Non-Hodgkin Lymphoma
ALK positive
T Cell Non-Hodgkin Lymphoma
crizotinib
Sensitive: C1 - Off-label
crizotinib
Sensitive
:
C1
crizotinib
Sensitive: C1 - Off-label
crizotinib
Sensitive
:
C1
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