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BIOMARKER:
ALK positive
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EML4-ALK variant 3 + TP53 mutation (5)
ALK fusion + ALK G1202R (4)
TP53 mutation + ALK positive (4)
ALK rearrangement + MET amplification (3)
EGFR wild-type + ALK wild-type + PD-L1 expression (3)
EML4-ALK fusion + ALK F1174L + ALK S1189C (3)
EML4-ALK fusion + ALK positive (3)
PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)
RANBP2-ALK rearrangement + TNFRSF8 expression (3)
ALK fusion + TP53 mutation (2)
ALK positive + ALK mutation (2)
ALK rearrangement + PD-L1 overepxression (2)
EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)
EML4-ALK fusion + ALK G1202R (2)
EML4-ALK fusion + ALK rearrangement (2)
EML4-ALK fusion + TP53 mutation (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
MYC amplification + ALK F1174L (2)
MYCN amplification + ALK F1174V (2)
MYCN amplification + ALK rearrangement (2)
STRN-ALK fusion + MET amplification (2)
ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)
ALK expression + RSRC1-ALK fusion (1)
ALK fusion + ALK G1269A (1)
ALK fusion + ALK I1179T (1)
ALK fusion + ALK V1180L (1)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK fusion + FAT3 mutation (1)
ALK fusion + FAT4 mutation (1)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK mutation + TMB-H (1)
ALK negative + S100A8 elevation (1)
ALK negative + S100A9 elevation (1)
ALK negative + SAA1 elevation (1)
ALK negative + SAA2 elevation (1)
ALK negative + TP53 deletion (1)
ALK positive + ALK G1202R (1)
ALK positive + ALK G1202R + ALK L1196M (1)
ALK positive + ALK L1196M + ALK D1203N (1)
ALK positive + DNMT3A N403Tfs* (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
ALK positive + ERCC3 E259D + GNAS A436_P459del (1)
ALK positive + MYC amplification + CCND1 deletion (1)
ALK psoitive + ALK G1202R + ALK F1174C (1)
ALK rearrangement + ABCC11 overexpression (1)
ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)
ALK rearrangement + BRCA2 F2801fs (1)
ALK rearrangement + CDKN2A deletion (1)
ALK rearrangement + CDKN2B deletion (1)
ALK rearrangement + CTLA4 overexpression (1)
ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)
ALK rearrangement + MET amplification (1)
ALK wild-type + NT5E overexpression + PD-L1 expression (1)
ALK-EML4_V3a + PD-L1 overexpression (1)
ALK-EML4_V3b + PD-L1 overexpression (1)
BCL2L11 deletion + ALK positive (1)
CPE-ALK fusion + TP53 wild-type (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + STRN-ALK fusion (1)
EGFR mutation + ALK negative + TMB-H (1)
EGFR negative + ALK negative + PD-L1 expression (1)
EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)
EML4-ALK fusion + ALK I1171N (1)
EML4-ALK fusion + ALK I1171T (1)
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)
EML4-ALK fusion + TMB-L (1)
EML4-ALK fusion v1insLTBP1 (1)
IDH2 mutation + ALK fusion (1)
KIF5B-ALK fusion + ALK L1196M (1)
MET amplification + KLC1-ALK fusion (1)
MET exon 14 mutation + ALK wild-type (1)
MYCN amplification + ALK F1174L (1)
MYCN amplification + ALK R1275Q (1)
PIK3CA mutation + ALK fusion (1)
PIK3CA mutation + ALK positive (1)
PTEN mutation + ALK positive (1)
SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)
SMARCA4 mutation + ALK positive (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
STRN-ALK fusion + KRAS G13D (1)
TMB-H + ALK rearrangement (1)
TPM3-NTRK1 fusion + ALK L1196M (1)
PD-L1 underexpression + ALK wild-type (0)
EML4-ALK variant 3 + TP53 mutation (5)
ALK fusion + ALK G1202R (4)
TP53 mutation + ALK positive (4)
ALK rearrangement + MET amplification (3)
EGFR wild-type + ALK wild-type + PD-L1 expression (3)
EML4-ALK fusion + ALK F1174L + ALK S1189C (3)
EML4-ALK fusion + ALK positive (3)
PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)
RANBP2-ALK rearrangement + TNFRSF8 expression (3)
ALK fusion + TP53 mutation (2)
ALK positive + ALK mutation (2)
ALK rearrangement + PD-L1 overepxression (2)
EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)
EML4-ALK fusion + ALK G1202R (2)
EML4-ALK fusion + ALK rearrangement (2)
EML4-ALK fusion + TP53 mutation (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
MYC amplification + ALK F1174L (2)
MYCN amplification + ALK F1174V (2)
MYCN amplification + ALK rearrangement (2)
STRN-ALK fusion + MET amplification (2)
ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)
ALK expression + RSRC1-ALK fusion (1)
ALK fusion + ALK G1269A (1)
ALK fusion + ALK I1179T (1)
ALK fusion + ALK V1180L (1)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK fusion + FAT3 mutation (1)
ALK fusion + FAT4 mutation (1)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK mutation + TMB-H (1)
ALK negative + S100A8 elevation (1)
ALK negative + S100A9 elevation (1)
ALK negative + SAA1 elevation (1)
ALK negative + SAA2 elevation (1)
ALK negative + TP53 deletion (1)
ALK positive + ALK G1202R (1)
ALK positive + ALK G1202R + ALK L1196M (1)
ALK positive + ALK L1196M + ALK D1203N (1)
ALK positive + DNMT3A N403Tfs* (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
ALK positive + ERCC3 E259D + GNAS A436_P459del (1)
ALK positive + MYC amplification + CCND1 deletion (1)
ALK psoitive + ALK G1202R + ALK F1174C (1)
ALK rearrangement + ABCC11 overexpression (1)
ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)
ALK rearrangement + BRCA2 F2801fs (1)
ALK rearrangement + CDKN2A deletion (1)
ALK rearrangement + CDKN2B deletion (1)
ALK rearrangement + CTLA4 overexpression (1)
ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)
ALK rearrangement + MET amplification (1)
ALK wild-type + NT5E overexpression + PD-L1 expression (1)
ALK-EML4_V3a + PD-L1 overexpression (1)
ALK-EML4_V3b + PD-L1 overexpression (1)
BCL2L11 deletion + ALK positive (1)
CPE-ALK fusion + TP53 wild-type (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + STRN-ALK fusion (1)
EGFR mutation + ALK negative + TMB-H (1)
EGFR negative + ALK negative + PD-L1 expression (1)
EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)
EML4-ALK fusion + ALK I1171N (1)
EML4-ALK fusion + ALK I1171T (1)
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)
EML4-ALK fusion + TMB-L (1)
EML4-ALK fusion v1insLTBP1 (1)
IDH2 mutation + ALK fusion (1)
KIF5B-ALK fusion + ALK L1196M (1)
MET amplification + KLC1-ALK fusion (1)
MET exon 14 mutation + ALK wild-type (1)
MYCN amplification + ALK F1174L (1)
MYCN amplification + ALK R1275Q (1)
PIK3CA mutation + ALK fusion (1)
PIK3CA mutation + ALK positive (1)
PTEN mutation + ALK positive (1)
SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)
SMARCA4 mutation + ALK positive (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
STRN-ALK fusion + KRAS G13D (1)
TMB-H + ALK rearrangement (1)
TPM3-NTRK1 fusion + ALK L1196M (1)
PD-L1 underexpression + ALK wild-type (0)
›
Related tests:
VENTANA ALK (D5F3) CDx Assay (13)
VENTANA ALK (D5F3) CDx Assay (13)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
lorlatinib
Sensitive: A1 - Approval
lorlatinib
Sensitive
:
A1
lorlatinib
Sensitive: A1 - Approval
lorlatinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
alectinib
Sensitive: A1 - Approval
alectinib
Sensitive
:
A1
alectinib
Sensitive: A1 - Approval
alectinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
brigatinib
Sensitive: A1 - Approval
brigatinib
Sensitive
:
A1
brigatinib
Sensitive: A1 - Approval
brigatinib
Sensitive
:
A1
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
crizotinib
Sensitive: A1 - Approval
crizotinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
ensartinib
Sensitive: A1 - Approval
ensartinib
Sensitive
:
A1
ensartinib
Sensitive: A1 - Approval
ensartinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
bevacizumab + atezolizumab
Sensitive: A1 - Approval
bevacizumab + atezolizumab
Sensitive
:
A1
bevacizumab + atezolizumab
Sensitive: A1 - Approval
bevacizumab + atezolizumab
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
ceritinib
Sensitive: A1 - Approval
ceritinib
Sensitive
:
A1
ceritinib
Sensitive: A1 - Approval
ceritinib
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
atezolizumab
Sensitive: A1 - Approval
atezolizumab
Sensitive
:
A1
atezolizumab
Sensitive: A1 - Approval
atezolizumab
Sensitive
:
A1
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
iruplinalkib
Sensitive: A1 - Approval
iruplinalkib
Sensitive
:
A1
iruplinalkib
Sensitive: A1 - Approval
iruplinalkib
Sensitive
:
A1
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
ALK positive
Peripheral T-cell Lymphoma
ALK positive
Peripheral T-cell Lymphoma
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
envonalkib
Sensitive: B - Late Trials
envonalkib
Sensitive
:
B
envonalkib
Sensitive: B - Late Trials
envonalkib
Sensitive
:
B
ALK positive
T Cell Non-Hodgkin Lymphoma
ALK positive
T Cell Non-Hodgkin Lymphoma
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
bevacizumab
Sensitive: B - Late Trials
bevacizumab
Sensitive
:
B
ALK positive
Non-Hodgkin’s Lymphoma
ALK positive
Non-Hodgkin’s Lymphoma
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
brentuximab vedotin
Sensitive: B - Late Trials
brentuximab vedotin
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
ALK positive
Lymphoma
ALK positive
Lymphoma
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
crizotinib
Sensitive: B - Late Trials
crizotinib
Sensitive
:
B
ALK positive
Non Small Cell Lung Cancer
ALK positive
Non Small Cell Lung Cancer
NVL-655
Sensitive: B - Late Trials
NVL-655
Sensitive
:
B
NVL-655
Sensitive: B - Late Trials
NVL-655
Sensitive
:
B
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ALK positive
Lung Non-Squamous Non-Small Cell Cancer
ensartinib
Sensitive: C1 - Off-label
ensartinib
Sensitive
:
C1
ensartinib
Sensitive: C1 - Off-label
ensartinib
Sensitive
:
C1
ALK positive
Lung Adenocarcinoma
ALK positive
Lung Adenocarcinoma
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Non-Small Cell Squamous Cancer
ALK positive
Lung Non-Small Cell Squamous Cancer
brigatinib
Sensitive: C1 - Off-label
brigatinib
Sensitive
:
C1
brigatinib
Sensitive: C1 - Off-label
brigatinib
Sensitive
:
C1
ALK positive
Neuroendocrine Tumor
ALK positive
Neuroendocrine Tumor
alectinib
Sensitive: C1 - Off-label
alectinib
Sensitive
:
C1
alectinib
Sensitive: C1 - Off-label
alectinib
Sensitive
:
C1
ALK positive
Neuroblastoma
ALK positive
Neuroblastoma
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Cancer
ALK positive
Lung Cancer
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
lorlatinib
Sensitive: C1 - Off-label
lorlatinib
Sensitive
:
C1
ALK positive
Lung Adenocarcinoma
ALK positive
Lung Adenocarcinoma
ceritinib
Sensitive: C1 - Off-label
ceritinib
Sensitive
:
C1
ceritinib
Sensitive: C1 - Off-label
ceritinib
Sensitive
:
C1
ALK positive
T Cell Non-Hodgkin Lymphoma
ALK positive
T Cell Non-Hodgkin Lymphoma
crizotinib
Sensitive: C1 - Off-label
crizotinib
Sensitive
:
C1
crizotinib
Sensitive: C1 - Off-label
crizotinib
Sensitive
:
C1
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