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    DRUG:

    OS47701

    i
    Other names: OS47701, NXD-30001
    Associations

    News

    Trials
    Company:
    Renovaro Biosci
    Drug class:
    HER2 inhibitor, HSP90 inhibitor
    Related drugs:
    Associations

    News

    Trials
    almost4years
    A Brain-Penetrating Hsp90 Inhibitor NXD30001 Inhibits Glioblastoma as a Monotherapy or in Combination With Radiation. (PubMed, Front Pharmacol)
    Radiotherapy solely increased median survival of tumor-bearing mice from 31 d to 38 d (P<0.05), while NXD30001 combined with radiation further extended survival to 43 d (P<0.05). We concluded that GSCs are more sensitive to NXD30001 than non-stem GBM cells, and NXD30001 in combination with radiation exerts better inhibitive effect in GBM progression than monotherapy.
    Journal • Combination therapy
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    EGFR (Epidermal growth factor receptor) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • NOTCH1 (Notch 1)
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    OS47701