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DRUG:

tanespimycin (BMS-722782)

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Company:

BMS

Drug class:

HSP90 inhibitor

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PIK3CA E545K	Squamous Cell Carcinoma of Head and Neck	PIK3CA E545K	Squamous Cell Carcinoma of Head and Neck	BMS-722782 Resistant: D – Preclinical BMS-722782 Resistant : D	BMS-722782 Resistant: D – Preclinical BMS-722782 Resistant : D
PIK3CA H1047R	Squamous Cell Carcinoma of Head and Neck	PIK3CA H1047R	Squamous Cell Carcinoma of Head and Neck	BMS-722782 Resistant: D – Preclinical BMS-722782 Resistant : D	BMS-722782 Resistant: D – Preclinical BMS-722782 Resistant : D
EGFR exon 19 deletion	Lung Cancer	EGFR exon 19 deletion	Lung Cancer	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D
EGFR T790M	Lung Cancer	EGFR T790M	Lung Cancer	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D
EGFR L858R	Lung Cancer	EGFR L858R	Lung Cancer	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D
EGFR H1975	Lung Cancer	EGFR H1975	Lung Cancer	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D
ALK rearrangement	Lung Cancer	ALK rearrangement	Lung Cancer	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D	BMS-722782 Sensitive: D – Preclinical BMS-722782 Sensitive : D
MYB-TYK2 fusion	B Acute Lymphoblastic Leukemia	MYB-TYK2 fusion	B Acute Lymphoblastic Leukemia	vorinostat + BMS-722782 Sensitive: D – Preclinical vorinostat + BMS-722782 Sensitive : D	vorinostat + BMS-722782 Sensitive: D – Preclinical vorinostat + BMS-722782 Sensitive : D
ZNF765 overexpression	Hepatocellular Cancer	ZNF765 overexpression	Hepatocellular Cancer	BMS-722782 Resistant: D – Preclinical BMS-722782 Resistant : D	BMS-722782 Resistant: D – Preclinical BMS-722782 Resistant : D