^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    MTX-211

    i
    Other names: MTX-211, MTX211, MTX 211
    Associations

    News

    Trials
    Company:
    Mekanistic Therap
    Drug class:
    EGFR inhibitor, PI3K inhibitor
    Related drugs:
    Associations

    News

    Trials
    6ms
    ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor MTX-211 in Cancer Cells. (PubMed, Int J Mol Sci)
    In summary, our findings indicate that MTX-211 acts as a substrate for ABCG2, underscoring the involvement of ABCG2 in the emergence of resistance to MTX-211. This finding carries clinical implications and merits further exploration.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • ABCG2 (ATP Binding Cassette Subfamily G Member 2)
    |
    MTX-211
    over1year
    MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer. (PubMed, Int J Mol Sci)
    This study provided evidence that MTX-211 effectively inhibited BLCA cell proliferation via depleting GSH levels through Keap1/NRF2/GCLM signaling pathway. Thus, MTX-211 could be a promising therapeutic agent for cancer.
    Journal
    |
    KEAP1 (Kelch Like ECH Associated Protein 1)
    |
    MTX-211