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DRUG:

LY294002

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Company:

Eli Lilly

Drug class:

PI3K inhibitor, AKT inhibitor, FAK inhibitor

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KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D
TP53 mutation	Colorectal Cancer	TP53 mutation	Colorectal Cancer	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D
MTOR H1968Y	Melanoma	MTOR H1968Y	Melanoma	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D
MTOR P2213S	Melanoma	MTOR P2213S	Melanoma	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D
MTOR S2215Y	Melanoma	MTOR S2215Y	Melanoma	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D	LY294002 Sensitive: D – Preclinical LY294002 Sensitive : D
BRCA2 mutation	Triple Negative Breast Cancer	BRCA2 mutation	Triple Negative Breast Cancer	talazoparib + LY294002 Sensitive: D – Preclinical talazoparib + LY294002 Sensitive : D	talazoparib + LY294002 Sensitive: D – Preclinical talazoparib + LY294002 Sensitive : D
BRCA1 mutation	Triple Negative Breast Cancer	BRCA1 mutation	Triple Negative Breast Cancer	talazoparib + LY294002 Sensitive: D – Preclinical talazoparib + LY294002 Sensitive : D	talazoparib + LY294002 Sensitive: D – Preclinical talazoparib + LY294002 Sensitive : D