Contact us to learn more about

our Premium Content: News alerts, weekly reports and conference planners

BIOMARKER:

PIK3CA mutation + ER positive

Contact us to learn more about our Premium Content:

News alerts, weekly reports and conference planners

Entrez ID:

Related biomarkers:

‹

PIK3CA mutation (108)

PIK3CA H1047R (45)

PIK3CA E545K (26)

ER mutation (18)

PIK3CA E542K (10)

ESR1 mutation (9)

ER positive + ESR1 mutation (6)

BRAF V600E + PIK3CA mutation (4)

EGFR mutation + PIK3CA mutation (4)

PIK3CA E545 (4)

PIK3CA H1047 (4)

PIK3CA K111N (4)

PIK3CA E542 (3)

PIK3CA E546 (3)

PIK3CA H1047L (3)

PIK3CA M1043I (3)

PIK3CA mutation + PTEN mutation (3)

PIK3CA wild-type (3)

ER negative + PIK3CA H1047R (2)

PIK3CA mutation + ESR1 mutation (2)

EGFR T790M + PIK3CA H1047R (2)

HER-2 V777L + PIK3CA H1047R (2)

PIK3CA C420R (2)

PIK3CA E545A (2)

PIK3CA N345K (2)

PIK3CA Q75E (2)

PIK3CA mutation + KRAS mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

ER D538G + ER F404L (1)

ER E380Q + ER F404L (1)

ER rs2234693 (1)

ESR1 rs1801132 (1)

ESR1 rs2228480 (1)

ESR1 rs2234693T>C (1)

ESR1 rs9322354 (1)

HR positive + PIK3CA H1047R (1)

HR positive + PIK3CA H1047R + ER D538G (1)

HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)

PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)

PIK3CA mutation + ER mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)

EGFR T790M + PIK3CA Mutation (1)

EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)

IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)

PIK3CA D350G (1)

PIK3CA E110K (1)

PIK3CA E453K (1)

PIK3CA E542Q (1)

PIK3CA E545G (1)

PIK3CA E545X (1)

PIK3CA G1049R (1)

PIK3CA G1049R + AKT1 E17K (1)

PIK3CA G106_108del (1)

PIK3CA H1047X (1)

PIK3CA I391M (1)

PIK3CA K944N (1)

PIK3CA K966E (1)

PIK3CA N345K + PIK3CA N1044K (1)

PIK3CA P449T (1)

PIK3CA Q546 (1)

PIK3CA Q546K (1)

PIK3CA R38C (1)

PIK3CA V955G (1)

PIK3CA mutation + AKT1 mutation + PTEN mutation (1)

PIK3CA mutation + EP300 mutation (1)

PIK3CA mutation + FGFR2 rearrangement (1)

PIK3CA mutation + HRAS mutation (1)

PIK3CA mutation + PTEN mutation + KRAS mutation (1)

PIK3CA mutation + TERT promoter mutation (1)

PIK3CA mutation + TTN mutation + IDH2 mutation (1)

PIK3CA wild-type + KRAS wild-type (1)

PIK3CA wild-type + PTEN wild-type (1)

PIK3CA Q546R (1)

HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

PIK3CA G542L (0)

PIK3CA mutation (108)

PIK3CA H1047R (45)

PIK3CA E545K (26)

ER mutation (18)

PIK3CA E542K (10)

ESR1 mutation (9)

ER positive + ESR1 mutation (6)

BRAF V600E + PIK3CA mutation (4)

EGFR mutation + PIK3CA mutation (4)

PIK3CA E545 (4)

PIK3CA H1047 (4)

PIK3CA K111N (4)

PIK3CA E542 (3)

PIK3CA E546 (3)

PIK3CA H1047L (3)

PIK3CA M1043I (3)

PIK3CA mutation + PTEN mutation (3)

PIK3CA wild-type (3)

ER negative + PIK3CA H1047R (2)

PIK3CA mutation + ESR1 mutation (2)

EGFR T790M + PIK3CA H1047R (2)

HER-2 V777L + PIK3CA H1047R (2)

PIK3CA C420R (2)

PIK3CA E545A (2)

PIK3CA N345K (2)

PIK3CA Q75E (2)

PIK3CA mutation + KRAS mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

ER D538G + ER F404L (1)

ER E380Q + ER F404L (1)

ER rs2234693 (1)

ESR1 rs1801132 (1)

ESR1 rs2228480 (1)

ESR1 rs2234693T>C (1)

ESR1 rs9322354 (1)

HR positive + PIK3CA H1047R (1)

HR positive + PIK3CA H1047R + ER D538G (1)

HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)

PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)

PIK3CA mutation + ER mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)

EGFR T790M + PIK3CA Mutation (1)

EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)

IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)

PIK3CA D350G (1)

PIK3CA E110K (1)

PIK3CA E453K (1)

PIK3CA E542Q (1)

PIK3CA E545G (1)

PIK3CA E545X (1)

PIK3CA G1049R (1)

PIK3CA G1049R + AKT1 E17K (1)

PIK3CA G106_108del (1)

PIK3CA H1047X (1)

PIK3CA I391M (1)

PIK3CA K944N (1)

PIK3CA K966E (1)

PIK3CA N345K + PIK3CA N1044K (1)

PIK3CA P449T (1)

PIK3CA Q546 (1)

PIK3CA Q546K (1)

PIK3CA R38C (1)

PIK3CA V955G (1)

PIK3CA mutation + AKT1 mutation + PTEN mutation (1)

PIK3CA mutation + EP300 mutation (1)

PIK3CA mutation + FGFR2 rearrangement (1)

PIK3CA mutation + HRAS mutation (1)

PIK3CA mutation + PTEN mutation + KRAS mutation (1)

PIK3CA mutation + TERT promoter mutation (1)

PIK3CA mutation + TTN mutation + IDH2 mutation (1)

PIK3CA wild-type + KRAS wild-type (1)

PIK3CA wild-type + PTEN wild-type (1)

PIK3CA Q546R (1)

HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

PIK3CA G542L (0)

›

PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	capivasertib Sensitive: A1 - Approval capivasertib Sensitive : A1	capivasertib Sensitive: A1 - Approval capivasertib Sensitive : A1
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	GDC-0032 Sensitive: B - Late Trials GDC-0032 Sensitive : B	GDC-0032 Sensitive: B - Late Trials GDC-0032 Sensitive : B
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	alpelisib Sensitive: C3 – Early Trials alpelisib Sensitive : C3	alpelisib Sensitive: C3 – Early Trials alpelisib Sensitive : C3
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	palbociclib + GDC-0032 Sensitive: C3 – Early Trials palbociclib + GDC-0032 Sensitive : C3	palbociclib + GDC-0032 Sensitive: C3 – Early Trials palbociclib + GDC-0032 Sensitive : C3
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	fulvestrant Sensitive: D – Preclinical fulvestrant Sensitive : D	fulvestrant Sensitive: D – Preclinical fulvestrant Sensitive : D
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	everolimus Sensitive: D – Preclinical everolimus Sensitive : D	everolimus Sensitive: D – Preclinical everolimus Sensitive : D
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	palbociclib + alpelisib Sensitive: D – Preclinical palbociclib + alpelisib Sensitive : D	palbociclib + alpelisib Sensitive: D – Preclinical palbociclib + alpelisib Sensitive : D
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	alpelisib + ribociclib Sensitive: D – Preclinical alpelisib + ribociclib Sensitive : D	alpelisib + ribociclib Sensitive: D – Preclinical alpelisib + ribociclib Sensitive : D
PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	PIK3CA mutation + ER positive	HER2 Negative Breast Cancer	LY4064809 Sensitive: D – Preclinical LY4064809 Sensitive : D	LY4064809 Sensitive: D – Preclinical LY4064809 Sensitive : D