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BIOMARKER:
MYC overexpression
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog
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Entrez ID:
4609
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BCL2 rearrangement + MYC amplification (2)
HR positive + MYC amplification (2)
MYC amplification + ALK F1174L (2)
MYC expression + MYC rearrangement (2)
MYC overexpression + IDH1 mutation (2)
MYC overexpression + IDH2 mutation (2)
MYC rearrangement + LDH elevation (2)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK positive + MYC amplification + CCND1 deletion (1)
EGFR T790M + MYC amplification (1)
HER-2 positive + MYC amplification (1)
HR positive + MYC mutation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
MYC mutation + ER positive (1)
miR-17-HG deletion + MYC positive (1)
BCL2 rearrangement + MYC amplification (2)
HR positive + MYC amplification (2)
MYC amplification + ALK F1174L (2)
MYC expression + MYC rearrangement (2)
MYC overexpression + IDH1 mutation (2)
MYC overexpression + IDH2 mutation (2)
MYC rearrangement + LDH elevation (2)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK positive + MYC amplification + CCND1 deletion (1)
EGFR T790M + MYC amplification (1)
HER-2 positive + MYC amplification (1)
HR positive + MYC mutation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
MYC mutation + ER positive (1)
miR-17-HG deletion + MYC positive (1)
›
Associations
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Trials
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MYC overexpression
Diffuse Large B Cell Lymphoma
MYC overexpression
Diffuse Large B Cell Lymphoma
tisagenlecleucel-T
Resistant: C3 – Early Trials
tisagenlecleucel-T
Resistant
:
C3
tisagenlecleucel-T
Resistant: C3 – Early Trials
tisagenlecleucel-T
Resistant
:
C3
MYC overexpression
Mediastinal B Cell Lymphoma
MYC overexpression
Mediastinal B Cell Lymphoma
lisocabtagene maraleucel
Resistant: C3 – Early Trials
lisocabtagene maraleucel
Resistant
:
C3
lisocabtagene maraleucel
Resistant: C3 – Early Trials
lisocabtagene maraleucel
Resistant
:
C3
MYC overexpression
Diffuse Large B Cell Lymphoma
MYC overexpression
Diffuse Large B Cell Lymphoma
azacitidine oral
Sensitive: C3 – Early Trials
azacitidine oral
Sensitive
:
C3
azacitidine oral
Sensitive: C3 – Early Trials
azacitidine oral
Sensitive
:
C3
MYC overexpression
Cervical Cancer
MYC overexpression
Cervical Cancer
GS-626510
Sensitive: D – Preclinical
GS-626510
Sensitive
:
D
GS-626510
Sensitive: D – Preclinical
GS-626510
Sensitive
:
D
MYC overexpression
Mantle Cell Lymphoma
MYC overexpression
Mantle Cell Lymphoma
TG-1701
Sensitive: D – Preclinical
TG-1701
Sensitive
:
D
TG-1701
Sensitive: D – Preclinical
TG-1701
Sensitive
:
D
MYC overexpression
Multiple Myeloma
MYC overexpression
Multiple Myeloma
bortezomib
Resistant: D – Preclinical
bortezomib
Resistant
:
D
bortezomib
Resistant: D – Preclinical
bortezomib
Resistant
:
D
MYC overexpression
Thyroid Gland Carcinoma
MYC overexpression
Thyroid Gland Carcinoma
MLN8237
Sensitive: D – Preclinical
MLN8237
Sensitive
:
D
MLN8237
Sensitive: D – Preclinical
MLN8237
Sensitive
:
D
MYC overexpression
Diffuse Large B Cell Lymphoma
MYC overexpression
Diffuse Large B Cell Lymphoma
INCB57643
Sensitive: D – Preclinical
INCB57643
Sensitive
:
D
INCB57643
Sensitive: D – Preclinical
INCB57643
Sensitive
:
D
MYC overexpression
Mantle Cell Lymphoma
MYC overexpression
Mantle Cell Lymphoma
venetoclax
Sensitive: D – Preclinical
venetoclax
Sensitive
:
D
venetoclax
Sensitive: D – Preclinical
venetoclax
Sensitive
:
D
MYC overexpression
Gastric Cancer
MYC overexpression
Gastric Cancer
WB100
Sensitive: D – Preclinical
WB100
Sensitive
:
D
WB100
Sensitive: D – Preclinical
WB100
Sensitive
:
D
MYC overexpression
Pancreatic Ductal Adenocarcinoma
MYC overexpression
Pancreatic Ductal Adenocarcinoma
WB100
Sensitive: D – Preclinical
WB100
Sensitive
:
D
WB100
Sensitive: D – Preclinical
WB100
Sensitive
:
D
MYC overexpression
Acute Myelogenous Leukemia
MYC overexpression
Acute Myelogenous Leukemia
WB100
Sensitive: D – Preclinical
WB100
Sensitive
:
D
WB100
Sensitive: D – Preclinical
WB100
Sensitive
:
D
MYC overexpression
Non Small Cell Lung Cancer
MYC overexpression
Non Small Cell Lung Cancer
MRT-2359
Sensitive: D – Preclinical
MRT-2359
Sensitive
:
D
MRT-2359
Sensitive: D – Preclinical
MRT-2359
Sensitive
:
D
MYC overexpression
Non Small Cell Lung Cancer
MYC overexpression
Non Small Cell Lung Cancer
ROS1 inhibitor
Resistant: D – Preclinical
ROS1 inhibitor
Resistant
:
D
ROS1 inhibitor
Resistant: D – Preclinical
ROS1 inhibitor
Resistant
:
D
MYC overexpression
Lymphoma
MYC overexpression
Lymphoma
brusatol
Sensitive: D – Preclinical
brusatol
Sensitive
:
D
brusatol
Sensitive: D – Preclinical
brusatol
Sensitive
:
D
MYC overexpression
Triple Negative Breast Cancer
MYC overexpression
Triple Negative Breast Cancer
PD-L1 inhibitor + MYC inhibitor
Sensitive: D – Preclinical
PD-L1 inhibitor + MYC inhibitor
Sensitive
:
D
PD-L1 inhibitor + MYC inhibitor
Sensitive: D – Preclinical
PD-L1 inhibitor + MYC inhibitor
Sensitive
:
D
MYC overexpression
Hepatocellular Cancer
MYC overexpression
Hepatocellular Cancer
HX301
Sensitive: D – Preclinical
HX301
Sensitive
:
D
HX301
Sensitive: D – Preclinical
HX301
Sensitive
:
D
MYC overexpression
Small Cell Lung Cancer
MYC overexpression
Small Cell Lung Cancer
ICX-101
Sensitive: D – Preclinical
ICX-101
Sensitive
:
D
ICX-101
Sensitive: D – Preclinical
ICX-101
Sensitive
:
D
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