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Association details:
| Biomarker: | MYC overexpression |
|---|---|
| Cancer: | Thyroid Gland Carcinoma |
| Drug: | alisertib (MLN8237) (Aurora kinase A inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer
Published date:
12/14/2018
Excerpt:
The data show that the levels of c-Myc protein were strongly associated with MLN8237 cellular response in thyroid cancer cells. Only the cells with high c-Myc expression exhibited growth inhibition upon MLN8237 treatment.
DOI:
10.1089/thy.2018.0183
