^
Association details:
| Biomarker: | MYC overexpression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | WB100 (MYC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors
Published date:
01/20/2022
Excerpt:
To assess in vivo the effect of WBC100 on c-Myc overexpressing cancer cells of hematological malignancies, we next established an orthotopic human AML model…At a low dose (0.1 mg kg–1), WBC100 also significantly inhibited tumor growth and prolonged survival of leukemia mice...WBC100 potently regresses c-Myc overexpressing AML in vivo...
DOI:
https://doi.org/10.1002/advs.202104344
