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Association details:
| Biomarker: | MYC overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | WB100 (MYC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors
Published date:
01/20/2022
Excerpt:
To further validate the efficacy of WBC100 on c-Myc overexpressing tumor in vivo, we established human gastric cancer mouse models using MGC-803 cell line with high c-Myc protein level…As expected, WBC100 potently inhibited the growth of MGC-803 tumor in a dose-dependent manner. WBC100 exhibited 70.62% of TGI at the low dose of 0.2 mg kg–1. Treatment of WBC100 at the dose of 0.4 mg kg–1 was sufficient to inhibit tumor growth and the TGI was up to 97.74%...
DOI:
https://doi.org/10.1002/advs.202104344
