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DRUG:

Matulane (procarbazine hydrochloride)

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Company:

Leadiant Biosci

Drug class:

Alkylating agent

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No biomarker	Astrocytoma	No biomarker	Astrocytoma	lomustine + procarbazine hydrochloride + vincristine liposomal Sensitive: A2 - Guideline lomustine + procarbazine hydrochloride + vincristine liposomal Sensitive : A2	lomustine + procarbazine hydrochloride + vincristine liposomal Sensitive: A2 - Guideline lomustine + procarbazine hydrochloride + vincristine liposomal Sensitive : A2
Chr del(1p)+ Chr del(19q)	Glioma	Chr del(1p)+ Chr del(19q)	Glioma	vincristine + lomustine + procarbazine hydrochloride Sensitive: C3 – Early Trials vincristine + lomustine + procarbazine hydrochloride Sensitive : C3	vincristine + lomustine + procarbazine hydrochloride Sensitive: C3 – Early Trials vincristine + lomustine + procarbazine hydrochloride Sensitive : C3
Chr del(1p)	Glioma	Chr del(1p)	Glioma	vincristine + lomustine + procarbazine hydrochloride Sensitive: C3 – Early Trials vincristine + lomustine + procarbazine hydrochloride Sensitive : C3	vincristine + lomustine + procarbazine hydrochloride Sensitive: C3 – Early Trials vincristine + lomustine + procarbazine hydrochloride Sensitive : C3
CDKN2A deletion	Glioma	CDKN2A deletion	Glioma	vincristine + lomustine + procarbazine hydrochloride Resistant: C3 – Early Trials vincristine + lomustine + procarbazine hydrochloride Resistant : C3	vincristine + lomustine + procarbazine hydrochloride Resistant: C3 – Early Trials vincristine + lomustine + procarbazine hydrochloride Resistant : C3