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    Association details:
    Biomarker:Chr del(1p)+ Chr del(19q)
    Cancer:Glioma
    Drug:vincristine (Tubulin polymerization inhibitor) +
    lomustine (Alkylating agent) +
    Matulane (procarbazine hydrochloride) (Alkylating agent)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    J Natl Cancer Inst
    Title:

    Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas

    Excerpt:
    Allelic loss of chromosomes 1p and 19q was associated with markedly better survival (RR 4 0.136; 95% CI 4 0.3-0.54), whereas CDKN2A gene deletions (RR 4 10.331; 95% CI 4 3.02- 35.37)...were associated with markedly worse survival.
    DOI:
    10.1093/jnci/90.19.1473