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DRUG:

Melflufen (melphalan flufenamide)

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Company:

Oncopeptides, SCBIO

Drug class:

Alkylating agent

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No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	melphalan flufenamide Sensitive: A1 - Approval melphalan flufenamide Sensitive : A1	melphalan flufenamide Sensitive: A1 - Approval melphalan flufenamide Sensitive : A1
XPNPEP1 overexpression	Multiple Myeloma	XPNPEP1 overexpression	Multiple Myeloma	melphalan flufenamide Sensitive: C3 – Early Trials melphalan flufenamide Sensitive : C3	melphalan flufenamide Sensitive: C3 – Early Trials melphalan flufenamide Sensitive : C3
TP53 mutation	Multiple Myeloma	TP53 mutation	Multiple Myeloma	melphalan flufenamide Sensitive: C3 – Early Trials melphalan flufenamide Sensitive : C3	melphalan flufenamide Sensitive: C3 – Early Trials melphalan flufenamide Sensitive : C3
Chr del(17p)	Multiple Myeloma	Chr del(17p)	Multiple Myeloma	melphalan flufenamide Sensitive: C3 – Early Trials melphalan flufenamide Sensitive : C3	melphalan flufenamide Sensitive: C3 – Early Trials melphalan flufenamide Sensitive : C3
DPP3 overexpression	Multiple Myeloma	DPP3 overexpression	Multiple Myeloma	melphalan flufenamide Sensitive: D – Preclinical melphalan flufenamide Sensitive : D	melphalan flufenamide Sensitive: D – Preclinical melphalan flufenamide Sensitive : D
RNPEP overexpression	Multiple Myeloma	RNPEP overexpression	Multiple Myeloma	melphalan flufenamide Sensitive: D – Preclinical melphalan flufenamide Sensitive : D	melphalan flufenamide Sensitive: D – Preclinical melphalan flufenamide Sensitive : D
BLMH overexpression	Multiple Myeloma	BLMH overexpression	Multiple Myeloma	melphalan flufenamide Sensitive: D – Preclinical melphalan flufenamide Sensitive : D	melphalan flufenamide Sensitive: D – Preclinical melphalan flufenamide Sensitive : D