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DRUG:

Temodex (temozolomide gel)

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News alerts, weekly reports and conference planners

Company:

Belmedpreparaty, Double Bond Pharmaceutical

Drug class:

DNA synthesis inhibitor, Alkylating agent

Related drugs:

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fludarabine oral (2)

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fosgemcitabine palabenamide (1)

asparagine cytarabine conjugate (1)

gemcitabine-releasing intravesical system (1)

mitomycin urothelial gel (1)

melphalan hepatic delivery system (1)

liposomal cisplatin (0)

pegylated liposomal mitomycin-c prodrug (0)

mercaptopurine oral suspension (0)

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bendamustine rapid infusion (0)

ranimustine (0)

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No biomarker	Astrocytoma	No biomarker	Astrocytoma	temozolomide gel Sensitive: A2 - Guideline temozolomide gel Sensitive : A2	temozolomide gel Sensitive: A2 - Guideline temozolomide gel Sensitive : A2
IDH1 mutation	Glioma	IDH1 mutation	Glioma	temozolomide gel Sensitive: B - Late Trials temozolomide gel Sensitive : B	temozolomide gel Sensitive: B - Late Trials temozolomide gel Sensitive : B
IDH2 mutation	Glioma	IDH2 mutation	Glioma	temozolomide gel Sensitive: B - Late Trials temozolomide gel Sensitive : B	temozolomide gel Sensitive: B - Late Trials temozolomide gel Sensitive : B
IDH2 mutation	Glioblastoma	IDH2 mutation	Glioblastoma	temozolomide gel Sensitive: C3 – Early Trials temozolomide gel Sensitive : C3	temozolomide gel Sensitive: C3 – Early Trials temozolomide gel Sensitive : C3
TP53 mutation	Glioma	TP53 mutation	Glioma	temozolomide gel Sensitive: C3 – Early Trials temozolomide gel Sensitive : C3	temozolomide gel Sensitive: C3 – Early Trials temozolomide gel Sensitive : C3
SETD2 mutation + MGMT promoter methylation	Glioblastoma	SETD2 mutation + MGMT promoter methylation	Glioblastoma	temozolomide gel Resistant: C3 – Early Trials temozolomide gel Resistant : C3	temozolomide gel Resistant: C3 – Early Trials temozolomide gel Resistant : C3
PIK3CA mutation + TTN mutation + IDH2 mutation	Glioma	PIK3CA mutation + TTN mutation + IDH2 mutation	Glioma	temozolomide gel Sensitive: C3 – Early Trials temozolomide gel Sensitive : C3	temozolomide gel Sensitive: C3 – Early Trials temozolomide gel Sensitive : C3