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DRUG:

Leukeran (chlorambucil)

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Company:

Aspen Pharma, GSK

Drug class:

Alkylating agent

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No biomarker	Marginal Zone Lymphoma	No biomarker	Marginal Zone Lymphoma	chlorambucil Sensitive: A2 - Guideline chlorambucil Sensitive : A2	chlorambucil Sensitive: A2 - Guideline chlorambucil Sensitive : A2
No biomarker	Follicular Lymphoma	No biomarker	Follicular Lymphoma	chlorambucil Sensitive: A2 - Guideline chlorambucil Sensitive : A2	chlorambucil Sensitive: A2 - Guideline chlorambucil Sensitive : A2
TP53 wild-type	Small Lymphocytic Lymphoma	TP53 wild-type	Small Lymphocytic Lymphoma	chlorambucil Sensitive: A2 - Guideline chlorambucil Sensitive : A2	chlorambucil Sensitive: A2 - Guideline chlorambucil Sensitive : A2
SF3B1 mutation	Chronic Lymphocytic Leukemia	SF3B1 mutation	Chronic Lymphocytic Leukemia	chlorambucil Resistant: B - Late Trials chlorambucil Resistant : B	chlorambucil Resistant: B - Late Trials chlorambucil Resistant : B
TP53 mutation	Chronic Lymphocytic Leukemia	TP53 mutation	Chronic Lymphocytic Leukemia	chlorambucil Resistant: B - Late Trials chlorambucil Resistant : B	chlorambucil Resistant: B - Late Trials chlorambucil Resistant : B
PD-L1 expression	Melanoma	PD-L1 expression	Melanoma	chlorambucil Sensitive: D – Preclinical chlorambucil Sensitive : D	chlorambucil Sensitive: D – Preclinical chlorambucil Sensitive : D
PD-L1 expression	Ovarian Cancer	PD-L1 expression	Ovarian Cancer	chlorambucil Sensitive: D – Preclinical chlorambucil Sensitive : D	chlorambucil Sensitive: D – Preclinical chlorambucil Sensitive : D