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BIOMARKER:
HER-2 S310F
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
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Entrez ID:
2064
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
HER-2 mutation (89)
HER-2 exon 20 insertion (27)
HER-2 L755S (26)
HER-2 A775_G776insYVMA (10)
HER-2 V777L (10)
HER-2 L755P (7)
HER-2 S310Y (6)
HER-2 G778_P780dup (5)
HER-2 L768S (4)
HER-2 Y772_A775dup (4)
HER-2 exon 20 mutation (4)
HER-2 C634R (3)
HER-2 D769Y (3)
HER-2 I655V (3)
HER-2 K753E (3)
HER-2 L869R (3)
HER-2 V777L + EGFR L858R (3)
HER-2 V842I (3)
HER-2 G776insV_C (2)
HER-2 G776insV_G (2)
HER-2 G778_S779insCPG (2)
HER-2 G780_P781dupGSP (2)
HER-2 H878Y (2)
HER-2 L755_T759del (2)
HER-2 L866M (2)
HER-2 T798M (2)
HER-2 T862A + HER-2 L755S (2)
HER-2 V773A (2)
HER-2 V773L (2)
HER-2 V777L + PIK3CA H1047R (2)
HER-2 exon 20 YVMA insertion (2)
HER-2 exon 20G776>VC insertion (2)
ALK rearrangement + HER-2 mutation (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR T790M + HER-2 mutation (1)
ERBB3 mutation + HER-2 mutation (1)
HER-2 1899‐1G>A (1)
HER-2 755_759del (1)
HER-2 778insGSP (1)
HER-2 A1170P (1)
HER-2 A775 (1)
HER-2 D769H (1)
HER-2 E395K (1)
HER-2 G309A (1)
HER-2 G660D + HER-2 S310F (1)
HER-2 G766V (1)
HER-2 G776L (1)
HER-2 G776S (1)
HER-2 K676R (1)
HER-2 L726I (1)
HER-2 M774delinsWLV (1)
HER-2 N857S (1)
HER-2 P780-Y781insGSP (1)
HER-2 P780ins (1)
HER-2 Q57R (1)
HER-2 Q680R (1)
HER-2 R647K (1)
HER-2 R678Q (1)
HER-2 R784G (1)
HER-2 R896C (1)
HER-2 R896G (1)
HER-2 S335C (1)
HER-2 T798I (1)
HER-2 T862A (1)
HER-2 V658E (1)
HER-2 V659D (1)
HER-2 YVMA (1)
HER-2 exon 17 mutation (1)
HER-2 exon 19 mutation (1)
HER-2 exon 20 G776delinsVC (1)
HER-2 exon 23 mutation (1)
HER-2 mutation + CDK6 mutation (1)
HER-2 mutation + HER-2 T798I (1)
HER-2 mutation + TP53 wild-type (1)
HER-2 rearrangement (1)
p95HER2 mutation (1)
HER-2 negative + HR positive + PTEN mutation (0)
HER-2 negative + ER positive + ESR1 mutation (0)
HER-2 negative + HR negative + BRCA mutation (0)
HER-2 negative + HR positive + AKT1 mutation (0)
HER-2 negative + HR positive + BRCA mutation (0)
HER-2 negative + HR positive + ESR1 mutation (0)
HER-2 negative + HR positive + ESR1 mutation + PIK3CA mutation (0)
HER-2 negative + HR positive + ESR1 wild-type (0)
HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)
HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)
HER-2 negative + HR positive + PIK3CA mutation (0)
HER2 L726I (0)
›
Associations
News
Trials
VERI cancer hierarchy
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HER-2 S310F
Solid Tumor
HER-2 S310F
Solid Tumor
BDTX-189
Sensitive: C2 – Inclusion Criteria
BDTX-189
Sensitive
:
C2
BDTX-189
Sensitive: C2 – Inclusion Criteria
BDTX-189
Sensitive
:
C2
HER-2 S310F
Breast Cancer
HER-2 S310F
Breast Cancer
trastuzumab + everolimus
Sensitive: C3 – Early Trials
trastuzumab + everolimus
Sensitive
:
C3
trastuzumab + everolimus
Sensitive: C3 – Early Trials
trastuzumab + everolimus
Sensitive
:
C3
HER-2 S310F
HER2 Negative Breast Cancer
HER-2 S310F
HER2 Negative Breast Cancer
trastuzumab + neratinib
Sensitive: C3 – Early Trials
trastuzumab + neratinib
Sensitive
:
C3
trastuzumab + neratinib
Sensitive: C3 – Early Trials
trastuzumab + neratinib
Sensitive
:
C3
HER-2 S310F
Lung Adenocarcinoma
HER-2 S310F
Lung Adenocarcinoma
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
HER-2 S310F
Colorectal Cancer
HER-2 S310F
Colorectal Cancer
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
HER-2 S310F
HER2 Negative Breast Cancer
HER-2 S310F
HER2 Negative Breast Cancer
lapatinib
Sensitive: C4 – Case Studies
lapatinib
Sensitive
:
C4
lapatinib
Sensitive: C4 – Case Studies
lapatinib
Sensitive
:
C4
HER-2 S310F
Gallbladder Cancer
HER-2 S310F
Gallbladder Cancer
lapatinib
Sensitive: C4 – Case Studies
lapatinib
Sensitive
:
C4
lapatinib
Sensitive: C4 – Case Studies
lapatinib
Sensitive
:
C4
HER-2 S310F
Non Small Cell Lung Cancer
HER-2 S310F
Non Small Cell Lung Cancer
ado-trastuzumab emtansine
Sensitive: D – Preclinical
ado-trastuzumab emtansine
Sensitive
:
D
ado-trastuzumab emtansine
Sensitive: D – Preclinical
ado-trastuzumab emtansine
Sensitive
:
D
HER-2 S310F
Colorectal Cancer
HER-2 S310F
Colorectal Cancer
cetuximab
Resistant: D – Preclinical
cetuximab
Resistant
:
D
cetuximab
Resistant: D – Preclinical
cetuximab
Resistant
:
D
HER-2 S310F
Colorectal Cancer
HER-2 S310F
Colorectal Cancer
panitumumab
Resistant: D – Preclinical
panitumumab
Resistant
:
D
panitumumab
Resistant: D – Preclinical
panitumumab
Resistant
:
D
^
^
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