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BIOMARKER:

HER-2 exon 20 insertion

i
Other names: ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Entrez ID:
HER-2 exon 20 insertion
Solid Tumor
BDTX-189
Sensitive: B - Late Trials
HER-2 exon 20 insertion
LUAD
ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
HER-2 exon 20 insertion
NSCLC
dacomitinib
Sensitive: C3 – Early Trials
HER-2 exon 20 insertion
NSCLC
rivoceranib + pyrotinib
Sensitive: C3 – Early Trials
HER-2 exon 20 insertion
NSCLC
KN046
Sensitive: C3 – Early Trials
HER-2 exon 20 insertion
LUAD
afatinib
Sensitive: C4 – Case Studies
HER-2 exon 20 insertion
HER2 Positive Breast Cancer
neratinib + ado-trastuzumab emtansine
Sensitive: D – Preclinical
HER-2 exon 20 insertion
HER2 Positive Breast Cancer
neratinib + fam-trastuzumab deruxtecan-nxki
Sensitive: D – Preclinical
HER-2 exon 20 insertion
LUAD
HM 78136B
Sensitive: D – Preclinical