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BIOMARKER:
HER-2 exon 20 insertion
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
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Entrez ID:
2064
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Related tests:
Guardant360® CDx (54)
Oncomine™ Dx Target Test (10)
Guardant360® CDx (54)
Oncomine™ Dx Target Test (10)
Associations
News
Trials
VERI cancer hierarchy
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HER-2 exon 20 insertion
Solid Tumor
HER-2 exon 20 insertion
Solid Tumor
BDTX-189
Sensitive: B - Late Trials
BDTX-189
Sensitive
:
B
BDTX-189
Sensitive: B - Late Trials
BDTX-189
Sensitive
:
B
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
rivoceranib + pyrotinib
Sensitive: C2 – Inclusion Criteria
rivoceranib + pyrotinib
Sensitive
:
C2
rivoceranib + pyrotinib
Sensitive: C2 – Inclusion Criteria
rivoceranib + pyrotinib
Sensitive
:
C2
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
pyrotinib
Sensitive: C2 – Inclusion Criteria
pyrotinib
Sensitive
:
C2
pyrotinib
Sensitive: C2 – Inclusion Criteria
pyrotinib
Sensitive
:
C2
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
poziotinib
Sensitive: C2 – Inclusion Criteria
poziotinib
Sensitive
:
C2
poziotinib
Sensitive: C2 – Inclusion Criteria
poziotinib
Sensitive
:
C2
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
trastuzumab + pertuzumab
Sensitive: C2 – Inclusion Criteria
trastuzumab + pertuzumab
Sensitive
:
C2
trastuzumab + pertuzumab
Sensitive: C2 – Inclusion Criteria
trastuzumab + pertuzumab
Sensitive
:
C2
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
mobocertinib
Sensitive: C2 – Inclusion Criteria
mobocertinib
Sensitive
:
C2
mobocertinib
Sensitive: C2 – Inclusion Criteria
mobocertinib
Sensitive
:
C2
HER-2 exon 20 insertion
Lung Adenocarcinoma
HER-2 exon 20 insertion
Lung Adenocarcinoma
ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
ado-trastuzumab emtansine
Sensitive
:
C3
ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
ado-trastuzumab emtansine
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
dacomitinib
Sensitive: C3 – Early Trials
dacomitinib
Sensitive
:
C3
dacomitinib
Sensitive: C3 – Early Trials
dacomitinib
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
KN046
Sensitive: C3 – Early Trials
KN046
Sensitive
:
C3
KN046
Sensitive: C3 – Early Trials
KN046
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
ado-trastuzumab emtansine
Sensitive
:
C3
ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
ado-trastuzumab emtansine
Sensitive
:
C3
HER-2 exon 20 insertion
HER2 Negative Breast Cancer
HER-2 exon 20 insertion
HER2 Negative Breast Cancer
trastuzumab + neratinib
Sensitive: C3 – Early Trials
trastuzumab + neratinib
Sensitive
:
C3
trastuzumab + neratinib
Sensitive: C3 – Early Trials
trastuzumab + neratinib
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
DZD9008
Sensitive: C3 – Early Trials
DZD9008
Sensitive
:
C3
DZD9008
Sensitive: C3 – Early Trials
DZD9008
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
BI 1810631
Sensitive: C3 – Early Trials
BI 1810631
Sensitive
:
C3
BI 1810631
Sensitive: C3 – Early Trials
BI 1810631
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER2 exon 20 mutation inhibitor
Sensitive: C3 – Early Trials
HER2 exon 20 mutation inhibitor
Sensitive
:
C3
HER2 exon 20 mutation inhibitor
Sensitive: C3 – Early Trials
HER2 exon 20 mutation inhibitor
Sensitive
:
C3
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
BAY 2927088
Sensitive: C3 – Early Trials
BAY 2927088
Sensitive
:
C3
BAY 2927088
Sensitive: C3 – Early Trials
BAY 2927088
Sensitive
:
C3
HER-2 exon 20 insertion
Lung Adenocarcinoma
HER-2 exon 20 insertion
Lung Adenocarcinoma
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
HER-2 exon 20 insertion
Lung Adenocarcinoma
HER-2 exon 20 insertion
Lung Adenocarcinoma
fam-trastuzumab deruxtecan-nxki
Sensitive: C4 – Case Studies
fam-trastuzumab deruxtecan-nxki
Sensitive
:
C4
fam-trastuzumab deruxtecan-nxki
Sensitive: C4 – Case Studies
fam-trastuzumab deruxtecan-nxki
Sensitive
:
C4
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
afatinib
Sensitive: C4 – Case Studies
afatinib
Sensitive
:
C4
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
fam-trastuzumab deruxtecan-nxki
Sensitive: C4 – Case Studies
fam-trastuzumab deruxtecan-nxki
Sensitive
:
C4
fam-trastuzumab deruxtecan-nxki
Sensitive: C4 – Case Studies
fam-trastuzumab deruxtecan-nxki
Sensitive
:
C4
HER-2 exon 20 insertion
HER2 Positive Breast Cancer
HER-2 exon 20 insertion
HER2 Positive Breast Cancer
neratinib + ado-trastuzumab emtansine
Sensitive: D – Preclinical
neratinib + ado-trastuzumab emtansine
Sensitive
:
D
neratinib + ado-trastuzumab emtansine
Sensitive: D – Preclinical
neratinib + ado-trastuzumab emtansine
Sensitive
:
D
HER-2 exon 20 insertion
HER2 Positive Breast Cancer
HER-2 exon 20 insertion
HER2 Positive Breast Cancer
neratinib + fam-trastuzumab deruxtecan-nxki
Sensitive: D – Preclinical
neratinib + fam-trastuzumab deruxtecan-nxki
Sensitive
:
D
neratinib + fam-trastuzumab deruxtecan-nxki
Sensitive: D – Preclinical
neratinib + fam-trastuzumab deruxtecan-nxki
Sensitive
:
D
HER-2 exon 20 insertion
Lung Adenocarcinoma
HER-2 exon 20 insertion
Lung Adenocarcinoma
poziotinib
Sensitive: D – Preclinical
poziotinib
Sensitive
:
D
poziotinib
Sensitive: D – Preclinical
poziotinib
Sensitive
:
D
HER-2 exon 20 insertion
Solid Tumor
HER-2 exon 20 insertion
Solid Tumor
TAS2940
Sensitive: D – Preclinical
TAS2940
Sensitive
:
D
TAS2940
Sensitive: D – Preclinical
TAS2940
Sensitive
:
D
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
HER-2 exon 20 insertion
Non Small Cell Lung Cancer
TY-4028
Sensitive: D – Preclinical
TY-4028
Sensitive
:
D
TY-4028
Sensitive: D – Preclinical
TY-4028
Sensitive
:
D
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