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Association details:
| Biomarker: | HER-2 S310F |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Kadcyla (ado-trastuzumab emtansine) (Microtubule inhibitor, HER2-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 3675: HER2 missense mutations in breast cancer cells do not alter HER2 internalization or sensitivity to T-DM1
Published date:
05/15/2020
Excerpt:
...cells with the HER2S310F mutation and the HER2A775>YVMA insertion showed enhanced HER2 endocytosis, consistent with clinical responses to T-DM1 in NSCLC patients with these mutations.
DOI:
10.1158/1538-7445.AM2020-3675
