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BIOMARKER:
HER-2 L755S
i
Other names:
ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
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Entrez ID:
2064
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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VERI cancer hierarchy
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HER-2 L755S
HER2 Negative Breast Cancer
HER-2 L755S
HER2 Negative Breast Cancer
neratinib
Sensitive: C2 – Inclusion Criteria
neratinib
Sensitive
:
C2
neratinib
Sensitive: C2 – Inclusion Criteria
neratinib
Sensitive
:
C2
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
trastuzumab
Resistant: C3 – Early Trials
trastuzumab
Resistant
:
C3
trastuzumab
Resistant: C3 – Early Trials
trastuzumab
Resistant
:
C3
HER-2 L755S
HER2 Negative Breast Cancer
HER-2 L755S
HER2 Negative Breast Cancer
trastuzumab + neratinib
Sensitive: C3 – Early Trials
trastuzumab + neratinib
Sensitive
:
C3
trastuzumab + neratinib
Sensitive: C3 – Early Trials
trastuzumab + neratinib
Sensitive
:
C3
HER-2 L755S
Salivary Gland Cancer
HER-2 L755S
Salivary Gland Cancer
ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
ado-trastuzumab emtansine
Sensitive
:
C3
ado-trastuzumab emtansine
Sensitive: C3 – Early Trials
ado-trastuzumab emtansine
Sensitive
:
C3
HER-2 L755S
Triple Negative Breast Cancer
HER-2 L755S
Triple Negative Breast Cancer
neratinib
Sensitive: C4 – Case Studies
neratinib
Sensitive
:
C4
neratinib
Sensitive: C4 – Case Studies
neratinib
Sensitive
:
C4
HER-2 L755S
HER2 Positive Breast Cancer
HER-2 L755S
HER2 Positive Breast Cancer
tucatinib
Resistant: D – Preclinical
tucatinib
Resistant
:
D
tucatinib
Resistant: D – Preclinical
tucatinib
Resistant
:
D
HER-2 L755S
Colorectal Cancer
HER-2 L755S
Colorectal Cancer
panitumumab
Resistant: D – Preclinical
panitumumab
Resistant
:
D
panitumumab
Resistant: D – Preclinical
panitumumab
Resistant
:
D
HER-2 L755S
HER2 Positive Breast Cancer
HER-2 L755S
HER2 Positive Breast Cancer
trastuzumab + tucatinib
Resistant: D – Preclinical
trastuzumab + tucatinib
Resistant
:
D
trastuzumab + tucatinib
Resistant: D – Preclinical
trastuzumab + tucatinib
Resistant
:
D
HER-2 L755S
HER2 Positive Breast Cancer
HER-2 L755S
HER2 Positive Breast Cancer
neratinib
Resistant: D – Preclinical
neratinib
Resistant
:
D
neratinib
Resistant: D – Preclinical
neratinib
Resistant
:
D
HER-2 L755S
HER2 Positive Breast Cancer
HER-2 L755S
HER2 Positive Breast Cancer
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
HER-2 L755S
Gastric Cancer
HER-2 L755S
Gastric Cancer
tucatinib
Sensitive: D – Preclinical
tucatinib
Sensitive
:
D
tucatinib
Sensitive: D – Preclinical
tucatinib
Sensitive
:
D
HER-2 L755S
Colorectal Cancer
HER-2 L755S
Colorectal Cancer
tucatinib
Sensitive: D – Preclinical
tucatinib
Sensitive
:
D
tucatinib
Sensitive: D – Preclinical
tucatinib
Sensitive
:
D
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
ado-trastuzumab emtansine
Resistant: D – Preclinical
ado-trastuzumab emtansine
Resistant
:
D
ado-trastuzumab emtansine
Resistant: D – Preclinical
ado-trastuzumab emtansine
Resistant
:
D
HER-2 L755S
Non Small Cell Lung Cancer
HER-2 L755S
Non Small Cell Lung Cancer
tucatinib
Sensitive: D – Preclinical
tucatinib
Sensitive
:
D
tucatinib
Sensitive: D – Preclinical
tucatinib
Sensitive
:
D
HER-2 L755S
Gastric Cancer
HER-2 L755S
Gastric Cancer
CL-387785
Sensitive: D – Preclinical
CL-387785
Sensitive
:
D
CL-387785
Sensitive: D – Preclinical
CL-387785
Sensitive
:
D
HER-2 L755S
Gastric Cancer
HER-2 L755S
Gastric Cancer
WZ4002
Sensitive: D – Preclinical
WZ4002
Sensitive
:
D
WZ4002
Sensitive: D – Preclinical
WZ4002
Sensitive
:
D
HER-2 L755S
Colorectal Cancer
HER-2 L755S
Colorectal Cancer
cetuximab
Resistant: D – Preclinical
cetuximab
Resistant
:
D
cetuximab
Resistant: D – Preclinical
cetuximab
Resistant
:
D
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
WZ4002
Sensitive: D – Preclinical
WZ4002
Sensitive
:
D
WZ4002
Sensitive: D – Preclinical
WZ4002
Sensitive
:
D
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
AEE788
Sensitive: D – Preclinical
AEE788
Sensitive
:
D
AEE788
Sensitive: D – Preclinical
AEE788
Sensitive
:
D
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
CL-387785
Sensitive: D – Preclinical
CL-387785
Sensitive
:
D
CL-387785
Sensitive: D – Preclinical
CL-387785
Sensitive
:
D
HER-2 L755S
HER2 Negative Breast Cancer
HER-2 L755S
HER2 Negative Breast Cancer
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
HER-2 L755S
Gastric Cancer
HER-2 L755S
Gastric Cancer
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
lapatinib
Resistant: D – Preclinical
lapatinib
Resistant
:
D
HER-2 L755S
Gastric Cancer
HER-2 L755S
Gastric Cancer
AEE788
Sensitive: D – Preclinical
AEE788
Sensitive
:
D
AEE788
Sensitive: D – Preclinical
AEE788
Sensitive
:
D
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
neratinib
Resistant: D – Preclinical
neratinib
Resistant
:
D
neratinib
Resistant: D – Preclinical
neratinib
Resistant
:
D
HER-2 L755S
Breast Cancer
HER-2 L755S
Breast Cancer
poziotinib
Sensitive: D – Preclinical
poziotinib
Sensitive
:
D
poziotinib
Sensitive: D – Preclinical
poziotinib
Sensitive
:
D
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