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BIOMARKER:
HER-2 mutation
i
Other names: ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Entrez ID:
HER-2 mutation
NSCLC
fam-trastuzumab deruxtecan-nxki
Sensitive
:
A2
HER-2 mutation
NSCLC
afatinib
Resistant
:
A2
HER-2 mutation
NSCLC
trastuzumab
Resistant
:
A2
HER-2 mutation
NSCLC
ado-trastuzumab emtansine
Sensitive
:
A2
HER-2 mutation
Solid Tumor
BDTX-189
Sensitive
:
B
HER-2 mutation
Breast Cancer
ribociclib
Sensitive
:
B
HER-2 mutation
Solid Tumor
tarloxotinib bromide
Sensitive
:
C2
HER-2 mutation
Hormone Receptor Positive Breast Cancer
trastuzumab + neratinib
Sensitive
:
C2
HER-2 mutation
Gastric Cancer
pyrotinib
Sensitive
:
C2
HER-2 mutation
Lung Cancer
pyrotinib
Sensitive
:
C2
HER-2 mutation
Urothelial Cancer
afatinib
Sensitive
:
C2
HER-2 mutation
NSCLC
tarloxotinib bromide
Sensitive
:
C2
HER-2 mutation
Solid Tumor
pyrotinib
Sensitive
:
C2
HER-2 mutation
Cervical Cancer
neratinib
Sensitive
:
C2
HER-2 mutation
NSCLC
trastuzumab + pertuzumab
Sensitive
:
C2
HER-2 mutation
NSCLC
pyrotinib
Sensitive
:
C2
HER-2 mutation
Breast Cancer
fam-trastuzumab deruxtecan-nxki
Sensitive
:
C2
HER-2 mutation
Gastroesophageal Junction Adenocarcinoma
pembrolizumab + margetuximab
Sensitive
:
C2
HER-2 mutation
Breast Cancer
neratinib
Sensitive
:
C2
HER-2 mutation
NSCLC
trastuzumab + neratinib
Sensitive
:
C3
HER-2 mutation
NSCLC
neratinib + temsirolimus
Sensitive
:
C3
HER-2 mutation
NSCLC
U3-1402
Sensitive
:
C3
HER-2 mutation
Biliary Tract Cancer
neratinib
Sensitive
:
C3
HER-2 mutation
LUAD
trastuzumab + pertuzumab
Sensitive
:
C3
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