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BIOMARKER:

HER-2 V777L

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Other names: ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Entrez ID:
HER-2 V777L
HER2 Negative Breast Cancer
neratinib
Sensitive: C2 – Inclusion Criteria
HER-2 V777L
Breast Cancer
trastuzumab
Resistant: C3 – Early Trials
HER-2 V777L
Gastric Cancer
tucatinib
Sensitive: D – Preclinical
HER-2 V777L
Breast Cancer
ado-trastuzumab emtansine
Resistant: D – Preclinical
HER-2 V777L
CRC
trastuzumab + tucatinib
Sensitive: D – Preclinical
HER-2 V777L
CRC
tucatinib
Sensitive: D – Preclinical
HER-2 V777L
NSCLC
tucatinib
Sensitive: D – Preclinical
HER-2 V777L
CRC
cetuximab
Resistant: D – Preclinical
HER-2 V777L
CRC
panitumumab
Resistant: D – Preclinical