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BIOMARKER:
ALK wild-type
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK rearrangement (43)
ALK mutation (20)
STRN-ALK rearrangement (10)
ALK translocation (9)
ALK F1174L (7)
ALK G1202R (7)
EGFR wild-type + ALK wild-type (7)
ALK C1156Y (6)
ALK A348D (5)
ALK F856S (5)
EML4-ALK rearrangement (5)
ALK G1202del (4)
ALK G1269A (4)
ALK I1171N (4)
ALK I1171T (4)
ALK rearrangement + TP53 mutation (4)
ALK F1174C (3)
ALK F1174V (3)
ALK F1245C (3)
ALK G1202K (3)
ALK I1171 (3)
ALK L1196M (3)
ALK R1275Q (3)
TYRO3 mutation + ALK mutation (3)
ALK C1156Y + ALK I1171T (2)
ALK C1156Y + ALK L1198F (2)
ALK E1210K (2)
ALK F1174L + ALK G1202R (2)
ALK I1171S (2)
ALK L1152R (2)
ALK L1198F (2)
ALK S1206Y (2)
ALK V1180L (2)
ALK V3a (2)
ALK V3b (2)
DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)
ALK C1156F (1)
ALK C1156Y + ALK G1202R (1)
ALK D1091N (1)
ALK D1203N (1)
ALK E1129V (1)
ALK F1174I (1)
ALK G1123S (1)
ALK G1128A (1)
ALK G1202L (1)
ALK G1202R + ALK F1174L + ALK T1151M (1)
ALK I1268L (1)
ALK L1152R + EGFR mutation (1)
ALK L1152V (1)
ALK L1196M + ALK C1156Y (1)
ALK L1196M + ALK G1202R (1)
ALK L1196M + ALK L1198F (1)
ALK L1198F + ALK G1202R (1)
ALK R1192P (1)
ALK R1209Q (1)
ALK R1231W (1)
ALK R214H (1)
ALK S1157F (1)
ALK T1151M (1)
ALK T1151R (1)
ALK TKD mutation (1)
ALK rearrangement + ALK L1196M + TP53 mutation (1)
ALK rearrangement + ALK R1275Q + TP53 mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + HER-2 mutation (1)
ALK rearrangement + KRAS mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
ALK rearrangement + TP53 wild-type (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR mutation + ALK mutation (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EML4-ALK I1171N + EML4-ALK L1196M (1)
EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)
LMO7-ALK rearrangement (1)
PLEKHH2-ALK rearrangement (1)
RMST-ALK rearrangement (1)
TP53 G245S + ALK rearrangement (1)
ALK mutation + TP53 mutation (0)
ALK rearrangement (43)
ALK mutation (20)
STRN-ALK rearrangement (10)
ALK translocation (9)
ALK F1174L (7)
ALK G1202R (7)
EGFR wild-type + ALK wild-type (7)
ALK C1156Y (6)
ALK A348D (5)
ALK F856S (5)
EML4-ALK rearrangement (5)
ALK G1202del (4)
ALK G1269A (4)
ALK I1171N (4)
ALK I1171T (4)
ALK rearrangement + TP53 mutation (4)
ALK F1174C (3)
ALK F1174V (3)
ALK F1245C (3)
ALK G1202K (3)
ALK I1171 (3)
ALK L1196M (3)
ALK R1275Q (3)
TYRO3 mutation + ALK mutation (3)
ALK C1156Y + ALK I1171T (2)
ALK C1156Y + ALK L1198F (2)
ALK E1210K (2)
ALK F1174L + ALK G1202R (2)
ALK I1171S (2)
ALK L1152R (2)
ALK L1198F (2)
ALK S1206Y (2)
ALK V1180L (2)
ALK V3a (2)
ALK V3b (2)
DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)
ALK C1156F (1)
ALK C1156Y + ALK G1202R (1)
ALK D1091N (1)
ALK D1203N (1)
ALK E1129V (1)
ALK F1174I (1)
ALK G1123S (1)
ALK G1128A (1)
ALK G1202L (1)
ALK G1202R + ALK F1174L + ALK T1151M (1)
ALK I1268L (1)
ALK L1152R + EGFR mutation (1)
ALK L1152V (1)
ALK L1196M + ALK C1156Y (1)
ALK L1196M + ALK G1202R (1)
ALK L1196M + ALK L1198F (1)
ALK L1198F + ALK G1202R (1)
ALK R1192P (1)
ALK R1209Q (1)
ALK R1231W (1)
ALK R214H (1)
ALK S1157F (1)
ALK T1151M (1)
ALK T1151R (1)
ALK TKD mutation (1)
ALK rearrangement + ALK L1196M + TP53 mutation (1)
ALK rearrangement + ALK R1275Q + TP53 mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + HER-2 mutation (1)
ALK rearrangement + KRAS mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
ALK rearrangement + TP53 wild-type (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR mutation + ALK mutation (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EML4-ALK I1171N + EML4-ALK L1196M (1)
EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)
LMO7-ALK rearrangement (1)
PLEKHH2-ALK rearrangement (1)
RMST-ALK rearrangement (1)
TP53 G245S + ALK rearrangement (1)
ALK mutation + TP53 mutation (0)
›
Associations
News
Trials
VERI cancer hierarchy
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ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
durvalumab + tremelimumab-actl
Sensitive: B - Late Trials
durvalumab + tremelimumab-actl
Sensitive
:
B
durvalumab + tremelimumab-actl
Sensitive: B - Late Trials
durvalumab + tremelimumab-actl
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
durvalumab
Sensitive: B - Late Trials
durvalumab
Sensitive
:
B
durvalumab
Sensitive: B - Late Trials
durvalumab
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
toripalimab-tpzi
Sensitive: B - Late Trials
toripalimab-tpzi
Sensitive
:
B
toripalimab-tpzi
Sensitive: B - Late Trials
toripalimab-tpzi
Sensitive
:
B
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
ALK wild-type
Lung Non-Small Cell Squamous Cancer
ALK wild-type
Lung Non-Small Cell Squamous Cancer
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
nivolumab + ipilimumab
Sensitive: B - Late Trials
nivolumab + ipilimumab
Sensitive
:
B
nivolumab + ipilimumab
Sensitive: B - Late Trials
nivolumab + ipilimumab
Sensitive
:
B
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
nivolumab + bevacizumab
Sensitive: B - Late Trials
nivolumab + bevacizumab
Sensitive
:
B
nivolumab + bevacizumab
Sensitive: B - Late Trials
nivolumab + bevacizumab
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
anlotinib + sintilimab
Sensitive: C2 – Inclusion Criteria
anlotinib + sintilimab
Sensitive
:
C2
anlotinib + sintilimab
Sensitive: C2 – Inclusion Criteria
anlotinib + sintilimab
Sensitive
:
C2
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
ivonescimab
Sensitive: C3 – Early Trials
ivonescimab
Sensitive
:
C3
ivonescimab
Sensitive: C3 – Early Trials
ivonescimab
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
pucotenlimab
Sensitive: C3 – Early Trials
pucotenlimab
Sensitive
:
C3
pucotenlimab
Sensitive: C3 – Early Trials
pucotenlimab
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
anlotinib + cadonilimab
Sensitive: C3 – Early Trials
anlotinib + cadonilimab
Sensitive
:
C3
anlotinib + cadonilimab
Sensitive: C3 – Early Trials
anlotinib + cadonilimab
Sensitive
:
C3
ALK wild-type
Lung Cancer
ALK wild-type
Lung Cancer
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
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