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BIOMARKER:
ALK wild-type
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
EML4-ALK variant 3 + TP53 mutation (5)
ALK fusion + ALK G1202R (4)
TP53 mutation + ALK positive (4)
ALK rearrangement + MET amplification (3)
EGFR wild-type + ALK wild-type + PD-L1 expression (3)
EML4-ALK fusion + ALK F1174L + ALK S1189C (3)
EML4-ALK fusion + ALK positive (3)
PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)
RANBP2-ALK rearrangement + TNFRSF8 expression (3)
ALK fusion + TP53 mutation (2)
ALK positive + ALK mutation (2)
ALK rearrangement + PD-L1 overepxression (2)
EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)
EML4-ALK fusion + ALK G1202R (2)
EML4-ALK fusion + ALK rearrangement (2)
EML4-ALK fusion + TP53 mutation (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
MYC amplification + ALK F1174L (2)
MYCN amplification + ALK F1174V (2)
MYCN amplification + ALK rearrangement (2)
STRN-ALK fusion + MET amplification (2)
ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)
ALK expression + RSRC1-ALK fusion (1)
ALK fusion + ALK G1269A (1)
ALK fusion + ALK I1179T (1)
ALK fusion + ALK V1180L (1)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK fusion + FAT3 mutation (1)
ALK fusion + FAT4 mutation (1)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK mutation + TMB-H (1)
ALK negative + S100A8 elevation (1)
ALK negative + S100A9 elevation (1)
ALK negative + SAA1 elevation (1)
ALK negative + SAA2 elevation (1)
ALK negative + TP53 deletion (1)
ALK positive + ALK G1202R (1)
ALK positive + ALK G1202R + ALK L1196M (1)
ALK positive + ALK L1196M + ALK D1203N (1)
ALK positive + DNMT3A N403Tfs* (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
ALK positive + ERCC3 E259D + GNAS A436_P459del (1)
ALK positive + MYC amplification + CCND1 deletion (1)
ALK psoitive + ALK G1202R + ALK F1174C (1)
ALK rearrangement + ABCC11 overexpression (1)
ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)
ALK rearrangement + BRCA2 F2801fs (1)
ALK rearrangement + CDKN2A deletion (1)
ALK rearrangement + CDKN2B deletion (1)
ALK rearrangement + CTLA4 overexpression (1)
ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)
ALK rearrangement + MET amplification (1)
ALK wild-type + NT5E overexpression + PD-L1 expression (1)
ALK-EML4_V3a + PD-L1 overexpression (1)
ALK-EML4_V3b + PD-L1 overexpression (1)
BCL2L11 deletion + ALK positive (1)
CPE-ALK fusion + TP53 wild-type (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + STRN-ALK fusion (1)
EGFR mutation + ALK negative + TMB-H (1)
EGFR negative + ALK negative + PD-L1 expression (1)
EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)
EML4-ALK fusion + ALK I1171N (1)
EML4-ALK fusion + ALK I1171T (1)
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)
EML4-ALK fusion + TMB-L (1)
EML4-ALK fusion v1insLTBP1 (1)
IDH2 mutation + ALK fusion (1)
KIF5B-ALK fusion + ALK L1196M (1)
MET amplification + KLC1-ALK fusion (1)
MET exon 14 mutation + ALK wild-type (1)
MYCN amplification + ALK F1174L (1)
MYCN amplification + ALK R1275Q (1)
PIK3CA mutation + ALK fusion (1)
PIK3CA mutation + ALK positive (1)
PTEN mutation + ALK positive (1)
SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)
SMARCA4 mutation + ALK positive (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
STRN-ALK fusion + KRAS G13D (1)
TMB-H + ALK rearrangement (1)
TPM3-NTRK1 fusion + ALK L1196M (1)
PD-L1 underexpression + ALK wild-type (0)
EML4-ALK variant 3 + TP53 mutation (5)
ALK fusion + ALK G1202R (4)
TP53 mutation + ALK positive (4)
ALK rearrangement + MET amplification (3)
EGFR wild-type + ALK wild-type + PD-L1 expression (3)
EML4-ALK fusion + ALK F1174L + ALK S1189C (3)
EML4-ALK fusion + ALK positive (3)
PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)
RANBP2-ALK rearrangement + TNFRSF8 expression (3)
ALK fusion + TP53 mutation (2)
ALK positive + ALK mutation (2)
ALK rearrangement + PD-L1 overepxression (2)
EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)
EML4-ALK fusion + ALK G1202R (2)
EML4-ALK fusion + ALK rearrangement (2)
EML4-ALK fusion + TP53 mutation (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
MYC amplification + ALK F1174L (2)
MYCN amplification + ALK F1174V (2)
MYCN amplification + ALK rearrangement (2)
STRN-ALK fusion + MET amplification (2)
ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)
ALK expression + RSRC1-ALK fusion (1)
ALK fusion + ALK G1269A (1)
ALK fusion + ALK I1179T (1)
ALK fusion + ALK V1180L (1)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK fusion + FAT3 mutation (1)
ALK fusion + FAT4 mutation (1)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK mutation + TMB-H (1)
ALK negative + S100A8 elevation (1)
ALK negative + S100A9 elevation (1)
ALK negative + SAA1 elevation (1)
ALK negative + SAA2 elevation (1)
ALK negative + TP53 deletion (1)
ALK positive + ALK G1202R (1)
ALK positive + ALK G1202R + ALK L1196M (1)
ALK positive + ALK L1196M + ALK D1203N (1)
ALK positive + DNMT3A N403Tfs* (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
ALK positive + ERCC3 E259D + GNAS A436_P459del (1)
ALK positive + MYC amplification + CCND1 deletion (1)
ALK psoitive + ALK G1202R + ALK F1174C (1)
ALK rearrangement + ABCC11 overexpression (1)
ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)
ALK rearrangement + BRCA2 F2801fs (1)
ALK rearrangement + CDKN2A deletion (1)
ALK rearrangement + CDKN2B deletion (1)
ALK rearrangement + CTLA4 overexpression (1)
ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)
ALK rearrangement + MET amplification (1)
ALK wild-type + NT5E overexpression + PD-L1 expression (1)
ALK-EML4_V3a + PD-L1 overexpression (1)
ALK-EML4_V3b + PD-L1 overexpression (1)
BCL2L11 deletion + ALK positive (1)
CPE-ALK fusion + TP53 wild-type (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + STRN-ALK fusion (1)
EGFR mutation + ALK negative + TMB-H (1)
EGFR negative + ALK negative + PD-L1 expression (1)
EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)
EML4-ALK fusion + ALK I1171N (1)
EML4-ALK fusion + ALK I1171T (1)
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)
EML4-ALK fusion + TMB-L (1)
EML4-ALK fusion v1insLTBP1 (1)
IDH2 mutation + ALK fusion (1)
KIF5B-ALK fusion + ALK L1196M (1)
MET amplification + KLC1-ALK fusion (1)
MET exon 14 mutation + ALK wild-type (1)
MYCN amplification + ALK F1174L (1)
MYCN amplification + ALK R1275Q (1)
PIK3CA mutation + ALK fusion (1)
PIK3CA mutation + ALK positive (1)
PTEN mutation + ALK positive (1)
SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)
SMARCA4 mutation + ALK positive (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
STRN-ALK fusion + KRAS G13D (1)
TMB-H + ALK rearrangement (1)
TPM3-NTRK1 fusion + ALK L1196M (1)
PD-L1 underexpression + ALK wild-type (0)
›
Associations
News
Trials
VERI cancer hierarchy
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ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
durvalumab + tremelimumab-actl
Sensitive: B - Late Trials
durvalumab + tremelimumab-actl
Sensitive
:
B
durvalumab + tremelimumab-actl
Sensitive: B - Late Trials
durvalumab + tremelimumab-actl
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
durvalumab
Sensitive: B - Late Trials
durvalumab
Sensitive
:
B
durvalumab
Sensitive: B - Late Trials
durvalumab
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
toripalimab-tpzi
Sensitive: B - Late Trials
toripalimab-tpzi
Sensitive
:
B
toripalimab-tpzi
Sensitive: B - Late Trials
toripalimab-tpzi
Sensitive
:
B
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
ALK wild-type
Lung Non-Small Cell Squamous Cancer
ALK wild-type
Lung Non-Small Cell Squamous Cancer
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
cemiplimab-rwlc
Sensitive: B - Late Trials
cemiplimab-rwlc
Sensitive
:
B
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
nivolumab + ipilimumab
Sensitive: B - Late Trials
nivolumab + ipilimumab
Sensitive
:
B
nivolumab + ipilimumab
Sensitive: B - Late Trials
nivolumab + ipilimumab
Sensitive
:
B
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
nivolumab + bevacizumab
Sensitive: B - Late Trials
nivolumab + bevacizumab
Sensitive
:
B
nivolumab + bevacizumab
Sensitive: B - Late Trials
nivolumab + bevacizumab
Sensitive
:
B
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
anlotinib + sintilimab
Sensitive: C2 – Inclusion Criteria
anlotinib + sintilimab
Sensitive
:
C2
anlotinib + sintilimab
Sensitive: C2 – Inclusion Criteria
anlotinib + sintilimab
Sensitive
:
C2
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
ivonescimab
Sensitive: C3 – Early Trials
ivonescimab
Sensitive
:
C3
ivonescimab
Sensitive: C3 – Early Trials
ivonescimab
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
tislelizumab-jsgr
Sensitive: C3 – Early Trials
tislelizumab-jsgr
Sensitive
:
C3
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
ALK wild-type
Lung Non-Squamous Non-Small Cell Cancer
pucotenlimab
Sensitive: C3 – Early Trials
pucotenlimab
Sensitive
:
C3
pucotenlimab
Sensitive: C3 – Early Trials
pucotenlimab
Sensitive
:
C3
ALK wild-type
Non Small Cell Lung Cancer
ALK wild-type
Non Small Cell Lung Cancer
anlotinib + cadonilimab
Sensitive: C3 – Early Trials
anlotinib + cadonilimab
Sensitive
:
C3
anlotinib + cadonilimab
Sensitive: C3 – Early Trials
anlotinib + cadonilimab
Sensitive
:
C3
ALK wild-type
Lung Cancer
ALK wild-type
Lung Cancer
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
^
^
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