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BIOMARKER:
ALK rearrangement
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK mutation (20)
ALK wild-type (18)
STRN-ALK rearrangement (10)
ALK translocation (9)
ALK F1174L (7)
ALK G1202R (7)
EGFR wild-type + ALK wild-type (7)
ALK C1156Y (6)
ALK A348D (5)
ALK F856S (5)
EML4-ALK rearrangement (5)
ALK G1202del (4)
ALK G1269A (4)
ALK I1171N (4)
ALK I1171T (4)
ALK rearrangement + TP53 mutation (4)
ALK F1174C (3)
ALK F1174V (3)
ALK F1245C (3)
ALK G1202K (3)
ALK I1171 (3)
ALK L1196M (3)
ALK R1275Q (3)
TYRO3 mutation + ALK mutation (3)
ALK C1156Y + ALK I1171T (2)
ALK C1156Y + ALK L1198F (2)
ALK E1210K (2)
ALK F1174L + ALK G1202R (2)
ALK I1171S (2)
ALK L1152R (2)
ALK L1198F (2)
ALK S1206Y (2)
ALK V1180L (2)
ALK V3a (2)
ALK V3b (2)
DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)
ALK C1156F (1)
ALK C1156Y + ALK G1202R (1)
ALK D1091N (1)
ALK D1203N (1)
ALK E1129V (1)
ALK F1174I (1)
ALK G1123S (1)
ALK G1128A (1)
ALK G1202L (1)
ALK G1202R + ALK F1174L + ALK T1151M (1)
ALK I1268L (1)
ALK L1152R + EGFR mutation (1)
ALK L1152V (1)
ALK L1196M + ALK C1156Y (1)
ALK L1196M + ALK G1202R (1)
ALK L1196M + ALK L1198F (1)
ALK L1198F + ALK G1202R (1)
ALK R1192P (1)
ALK R1209Q (1)
ALK R1231W (1)
ALK R214H (1)
ALK S1157F (1)
ALK T1151M (1)
ALK T1151R (1)
ALK TKD mutation (1)
ALK rearrangement + ALK L1196M + TP53 mutation (1)
ALK rearrangement + ALK R1275Q + TP53 mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + HER-2 mutation (1)
ALK rearrangement + KRAS mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
ALK rearrangement + TP53 wild-type (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR mutation + ALK mutation (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EML4-ALK I1171N + EML4-ALK L1196M (1)
EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)
LMO7-ALK rearrangement (1)
PLEKHH2-ALK rearrangement (1)
RMST-ALK rearrangement (1)
TP53 G245S + ALK rearrangement (1)
ALK mutation + TP53 mutation (0)
ALK mutation (20)
ALK wild-type (18)
STRN-ALK rearrangement (10)
ALK translocation (9)
ALK F1174L (7)
ALK G1202R (7)
EGFR wild-type + ALK wild-type (7)
ALK C1156Y (6)
ALK A348D (5)
ALK F856S (5)
EML4-ALK rearrangement (5)
ALK G1202del (4)
ALK G1269A (4)
ALK I1171N (4)
ALK I1171T (4)
ALK rearrangement + TP53 mutation (4)
ALK F1174C (3)
ALK F1174V (3)
ALK F1245C (3)
ALK G1202K (3)
ALK I1171 (3)
ALK L1196M (3)
ALK R1275Q (3)
TYRO3 mutation + ALK mutation (3)
ALK C1156Y + ALK I1171T (2)
ALK C1156Y + ALK L1198F (2)
ALK E1210K (2)
ALK F1174L + ALK G1202R (2)
ALK I1171S (2)
ALK L1152R (2)
ALK L1198F (2)
ALK S1206Y (2)
ALK V1180L (2)
ALK V3a (2)
ALK V3b (2)
DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)
ALK C1156F (1)
ALK C1156Y + ALK G1202R (1)
ALK D1091N (1)
ALK D1203N (1)
ALK E1129V (1)
ALK F1174I (1)
ALK G1123S (1)
ALK G1128A (1)
ALK G1202L (1)
ALK G1202R + ALK F1174L + ALK T1151M (1)
ALK I1268L (1)
ALK L1152R + EGFR mutation (1)
ALK L1152V (1)
ALK L1196M + ALK C1156Y (1)
ALK L1196M + ALK G1202R (1)
ALK L1196M + ALK L1198F (1)
ALK L1198F + ALK G1202R (1)
ALK R1192P (1)
ALK R1209Q (1)
ALK R1231W (1)
ALK R214H (1)
ALK S1157F (1)
ALK T1151M (1)
ALK T1151R (1)
ALK TKD mutation (1)
ALK rearrangement + ALK L1196M + TP53 mutation (1)
ALK rearrangement + ALK R1275Q + TP53 mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + HER-2 mutation (1)
ALK rearrangement + KRAS mutation (1)
ALK rearrangement + PIK3CA mutation (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
ALK rearrangement + TP53 wild-type (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR mutation + ALK mutation (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EML4-ALK I1171N + EML4-ALK L1196M (1)
EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)
LMO7-ALK rearrangement (1)
PLEKHH2-ALK rearrangement (1)
RMST-ALK rearrangement (1)
TP53 G245S + ALK rearrangement (1)
ALK mutation + TP53 mutation (0)
›
Related tests:
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Vysis ALK Break Apart FISH Probe Kit (2)
HTG EdgeSeq ALKPlus Assay EU
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Vysis ALK Break Apart FISH Probe Kit (2)
HTG EdgeSeq ALKPlus Assay EU
Associations
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Reset Filters
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ALK inhibitor
Sensitive: A2 - Guideline
ALK inhibitor
Sensitive
:
A2
ALK inhibitor
Sensitive: A2 - Guideline
ALK inhibitor
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ceritinib
Sensitive: B - Late Trials
ceritinib
Sensitive
:
B
ceritinib
Sensitive: B - Late Trials
ceritinib
Sensitive
:
B
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
nivolumab
Sensitive: C2 – Inclusion Criteria
nivolumab
Sensitive
:
C2
nivolumab
Sensitive: C2 – Inclusion Criteria
nivolumab
Sensitive
:
C2
ALK rearrangement
Solid Tumor
ALK rearrangement
Solid Tumor
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
bevacizumab + alectinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + alectinib
Sensitive
:
C2
bevacizumab + alectinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + alectinib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ceritinib + ribociclib
Sensitive: C2 – Inclusion Criteria
ceritinib + ribociclib
Sensitive
:
C2
ceritinib + ribociclib
Sensitive: C2 – Inclusion Criteria
ceritinib + ribociclib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
camrelizumab + rivoceranib
Sensitive: C2 – Inclusion Criteria
camrelizumab + rivoceranib
Sensitive
:
C2
camrelizumab + rivoceranib
Sensitive: C2 – Inclusion Criteria
camrelizumab + rivoceranib
Sensitive
:
C2
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab + atezolizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab + atezolizumab
Sensitive
:
C2
bevacizumab + atezolizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab + atezolizumab
Sensitive
:
C2
ALK rearrangement
Lung Cancer
ALK rearrangement
Lung Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
ALK rearrangement
Lung Cancer
ALK rearrangement
Lung Cancer
crizotinib + lorlatinib
Sensitive: C2 – Inclusion Criteria
crizotinib + lorlatinib
Sensitive
:
C2
crizotinib + lorlatinib
Sensitive: C2 – Inclusion Criteria
crizotinib + lorlatinib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
AUY922
Sensitive: C2 – Inclusion Criteria
AUY922
Sensitive
:
C2
AUY922
Sensitive: C2 – Inclusion Criteria
AUY922
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
bevacizumab + crizotinib
Sensitive: C3 – Early Trials
bevacizumab + crizotinib
Sensitive
:
C3
bevacizumab + crizotinib
Sensitive: C3 – Early Trials
bevacizumab + crizotinib
Sensitive
:
C3
ALK rearrangement
Lung Adenocarcinoma
ALK rearrangement
Lung Adenocarcinoma
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
ALK rearrangement
Non-Hodgkin’s Lymphoma
ALK rearrangement
Non-Hodgkin’s Lymphoma
ceritinib
Sensitive: C3 – Early Trials
ceritinib
Sensitive
:
C3
ceritinib
Sensitive: C3 – Early Trials
ceritinib
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
IPI-504
Sensitive: C3 – Early Trials
IPI-504
Sensitive
:
C3
IPI-504
Sensitive: C3 – Early Trials
IPI-504
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ipilimumab
Sensitive: C3 – Early Trials
ipilimumab
Sensitive
:
C3
ipilimumab
Sensitive: C3 – Early Trials
ipilimumab
Sensitive
:
C3
ALK rearrangement
Lung Non-Small Cell Squamous Cancer
ALK rearrangement
Lung Non-Small Cell Squamous Cancer
ALK inhibitor
Sensitive: C3 – Early Trials
ALK inhibitor
Sensitive
:
C3
ALK inhibitor
Sensitive: C3 – Early Trials
ALK inhibitor
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
iruplinalkib
Sensitive: C3 – Early Trials
iruplinalkib
Sensitive
:
C3
iruplinalkib
Sensitive: C3 – Early Trials
iruplinalkib
Sensitive
:
C3
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
ALK rearrangement
Renal Cell Carcinoma
ALK rearrangement
Renal Cell Carcinoma
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
ALK rearrangement
Sarcoma
ALK rearrangement
Sarcoma
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
^
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