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BIOMARKER:
ALK rearrangement
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK amplification (3)
ALK amplification (3)
›
Related tests:
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Vysis ALK Break Apart FISH Probe Kit (2)
HTG EdgeSeq ALKPlus Assay EU
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Vysis ALK Break Apart FISH Probe Kit (2)
HTG EdgeSeq ALKPlus Assay EU
Associations
News
Trials
VERI cancer hierarchy
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ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
alectinib
Sensitive: A2 - Guideline
alectinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ALK inhibitor
Sensitive: A2 - Guideline
ALK inhibitor
Sensitive
:
A2
ALK inhibitor
Sensitive: A2 - Guideline
ALK inhibitor
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
brigatinib
Sensitive: A2 - Guideline
brigatinib
Sensitive
:
A2
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ceritinib
Sensitive: B - Late Trials
ceritinib
Sensitive
:
B
ceritinib
Sensitive: B - Late Trials
ceritinib
Sensitive
:
B
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
nivolumab
Sensitive: C2 – Inclusion Criteria
nivolumab
Sensitive
:
C2
nivolumab
Sensitive: C2 – Inclusion Criteria
nivolumab
Sensitive
:
C2
ALK rearrangement
Solid Tumor
ALK rearrangement
Solid Tumor
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
bevacizumab + alectinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + alectinib
Sensitive
:
C2
bevacizumab + alectinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + alectinib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ceritinib + ribociclib
Sensitive: C2 – Inclusion Criteria
ceritinib + ribociclib
Sensitive
:
C2
ceritinib + ribociclib
Sensitive: C2 – Inclusion Criteria
ceritinib + ribociclib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
camrelizumab + rivoceranib
Sensitive: C2 – Inclusion Criteria
camrelizumab + rivoceranib
Sensitive
:
C2
camrelizumab + rivoceranib
Sensitive: C2 – Inclusion Criteria
camrelizumab + rivoceranib
Sensitive
:
C2
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab + atezolizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab + atezolizumab
Sensitive
:
C2
bevacizumab + atezolizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab + atezolizumab
Sensitive
:
C2
ALK rearrangement
Lung Cancer
ALK rearrangement
Lung Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
ALK rearrangement
Lung Cancer
ALK rearrangement
Lung Cancer
crizotinib + lorlatinib
Sensitive: C2 – Inclusion Criteria
crizotinib + lorlatinib
Sensitive
:
C2
crizotinib + lorlatinib
Sensitive: C2 – Inclusion Criteria
crizotinib + lorlatinib
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
AUY922
Sensitive: C2 – Inclusion Criteria
AUY922
Sensitive
:
C2
AUY922
Sensitive: C2 – Inclusion Criteria
AUY922
Sensitive
:
C2
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
bevacizumab + crizotinib
Sensitive: C3 – Early Trials
bevacizumab + crizotinib
Sensitive
:
C3
bevacizumab + crizotinib
Sensitive: C3 – Early Trials
bevacizumab + crizotinib
Sensitive
:
C3
ALK rearrangement
Lung Adenocarcinoma
ALK rearrangement
Lung Adenocarcinoma
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
ALK rearrangement
Non-Hodgkin’s Lymphoma
ALK rearrangement
Non-Hodgkin’s Lymphoma
ceritinib
Sensitive: C3 – Early Trials
ceritinib
Sensitive
:
C3
ceritinib
Sensitive: C3 – Early Trials
ceritinib
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
IPI-504
Sensitive: C3 – Early Trials
IPI-504
Sensitive
:
C3
IPI-504
Sensitive: C3 – Early Trials
IPI-504
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
ipilimumab
Sensitive: C3 – Early Trials
ipilimumab
Sensitive
:
C3
ipilimumab
Sensitive: C3 – Early Trials
ipilimumab
Sensitive
:
C3
ALK rearrangement
Lung Non-Small Cell Squamous Cancer
ALK rearrangement
Lung Non-Small Cell Squamous Cancer
ALK inhibitor
Sensitive: C3 – Early Trials
ALK inhibitor
Sensitive
:
C3
ALK inhibitor
Sensitive: C3 – Early Trials
ALK inhibitor
Sensitive
:
C3
ALK rearrangement
Non Small Cell Lung Cancer
ALK rearrangement
Non Small Cell Lung Cancer
iruplinalkib
Sensitive: C3 – Early Trials
iruplinalkib
Sensitive
:
C3
iruplinalkib
Sensitive: C3 – Early Trials
iruplinalkib
Sensitive
:
C3
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
ALK rearrangement
Lung Non-Squamous Non-Small Cell Cancer
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
alectinib
Sensitive: C3 – Early Trials
alectinib
Sensitive
:
C3
ALK rearrangement
Renal Cell Carcinoma
ALK rearrangement
Renal Cell Carcinoma
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
ALK rearrangement
Sarcoma
ALK rearrangement
Sarcoma
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
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