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BIOMARKER:

ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion

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Entrez ID:

238; 4609; 2261; 595

Related biomarkers:

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EML4-ALK variant 3 + TP53 mutation (5)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

BCL2 rearrangement + MYC amplification (2)

HR positive + MYC amplification (2)

MYC expression + MYC rearrangement (2)

MYC overexpression + IDH1 mutation (2)

MYC overexpression + IDH2 mutation (2)

MYC rearrangement + LDH elevation (2)

PD-L1 overexpression + FGFR3 amplification (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TMB-H + ALK rearrangement (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

EGFR T790M + MYC amplification (1)

HER-2 positive + MYC amplification (1)

HR positive + MYC mutation (1)

IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)

IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

MYC amplification + BCL2 amplification + TNFRSF8 expression (1)

MYC mutation + ER positive (1)

miR-17-HG deletion + MYC positive (1)

ER positive + FGFR3 amplification (1)

FGFR2 underexpression + FGFR3 mutation (1)

FGFR3-TACC3 fusion + FGFR3 V555M (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

TERT C228T + FGFR3 amplification + FGFR3-TACC3 fusion (1)

CCND1 mutation + HR positive (1)

EGFR exon 19 deletion + CCND1 overexpression (1)

EGFR mutation + CCND1 expression + CDKN2A deletion (1)

ER L536H + ER D538G + CCND1 amplification (1)

ER positive + ESR1 mutation + CCND1 amplification (1)

HR positive + CCND1 amplification (1)

PD-L1 underexpression + ALK wild-type (0)

EML4-ALK variant 3 + TP53 mutation (5)

ALK fusion + ALK G1202R (4)

TP53 mutation + ALK positive (4)

ALK rearrangement + MET amplification (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

EML4-ALK fusion + ALK F1174L + ALK S1189C (3)

EML4-ALK fusion + ALK positive (3)

PPFIBP1-ALK translocation + ALK G1202R + ALK V1180L (3)

RANBP2-ALK rearrangement + TNFRSF8 expression (3)

ALK fusion + TP53 mutation (2)

ALK positive + ALK mutation (2)

ALK rearrangement + PD-L1 overepxression (2)

EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)

EML4-ALK fusion + ALK G1202R (2)

EML4-ALK fusion + ALK rearrangement (2)

EML4-ALK fusion + TP53 mutation (2)

EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)

MYC amplification + ALK F1174L (2)

MYCN amplification + ALK F1174V (2)

MYCN amplification + ALK rearrangement (2)

STRN-ALK fusion + MET amplification (2)

BCL2 rearrangement + MYC amplification (2)

HR positive + MYC amplification (2)

MYC expression + MYC rearrangement (2)

MYC overexpression + IDH1 mutation (2)

MYC overexpression + IDH2 mutation (2)

MYC rearrangement + LDH elevation (2)

PD-L1 overexpression + FGFR3 amplification (2)

ALK exon 23 C1156Y missense mutation+ LOC101927285-ALK fusion (1)

ALK expression + RSRC1-ALK fusion (1)

ALK fusion + ALK G1269A (1)

ALK fusion + ALK I1179T (1)

ALK fusion + ALK V1180L (1)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK fusion + FAT3 mutation (1)

ALK fusion + FAT4 mutation (1)

ALK mutation + TMB-H (1)

ALK negative + S100A8 elevation (1)

ALK negative + S100A9 elevation (1)

ALK negative + SAA1 elevation (1)

ALK negative + SAA2 elevation (1)

ALK negative + TP53 deletion (1)

ALK positive + ALK G1202R (1)

ALK positive + ALK G1202R + ALK L1196M (1)

ALK positive + ALK L1196M + ALK D1203N (1)

ALK positive + DNMT3A N403Tfs* (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

ALK positive + ERCC3 E259D + GNAS A436_P459del (1)

ALK positive + MYC amplification + CCND1 deletion (1)

ALK psoitive + ALK G1202R + ALK F1174C (1)

ALK rearrangement + ABCC11 overexpression (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

ALK rearrangement + BRCA2 F2801fs (1)

ALK rearrangement + CDKN2A deletion (1)

ALK rearrangement + CDKN2B deletion (1)

ALK rearrangement + CTLA4 overexpression (1)

ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)

ALK rearrangement + MET amplification (1)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BCL2L11 deletion + ALK positive (1)

CPE-ALK fusion + TP53 wild-type (1)

EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)

EGFR exon 19 deletion + STRN-ALK fusion (1)

EGFR mutation + ALK negative + TMB-H (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

EML4-ALK fusion + ALK I1171N (1)

EML4-ALK fusion + ALK I1171T (1)

EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)

EML4-ALK fusion + TMB-L (1)

EML4-ALK fusion v1insLTBP1 (1)

IDH2 mutation + ALK fusion (1)

KIF5B-ALK fusion + ALK L1196M (1)

MET amplification + KLC1-ALK fusion (1)

MET exon 14 mutation + ALK wild-type (1)

MYCN amplification + ALK F1174L (1)

MYCN amplification + ALK R1275Q (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PTEN mutation + ALK positive (1)

SLC8A1-PKDCC-ALK fusion + ALK overexpression (1)

SMARCA4 mutation + ALK positive (1)

STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)

STRN-ALK fusion + KRAS G13D (1)

TMB-H + ALK rearrangement (1)

TPM3-NTRK1 fusion + ALK L1196M (1)

EGFR T790M + MYC amplification (1)

HER-2 positive + MYC amplification (1)

HR positive + MYC mutation (1)

IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)

IDH2 mutation + MYC amplification + MAPRE1 overexpression (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

MYC amplification + BCL2 amplification + TNFRSF8 expression (1)

MYC mutation + ER positive (1)

miR-17-HG deletion + MYC positive (1)

ER positive + FGFR3 amplification (1)

FGFR2 underexpression + FGFR3 mutation (1)

FGFR3-TACC3 fusion + FGFR3 V555M (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

TERT C228T + FGFR3 amplification + FGFR3-TACC3 fusion (1)

CCND1 mutation + HR positive (1)

EGFR exon 19 deletion + CCND1 overexpression (1)

EGFR mutation + CCND1 expression + CDKN2A deletion (1)

ER L536H + ER D538G + CCND1 amplification (1)

ER positive + ESR1 mutation + CCND1 amplification (1)

HR positive + CCND1 amplification (1)

PD-L1 underexpression + ALK wild-type (0)

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ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion

Non Small Cell Lung Cancer

Resistant: C4 – Case Studies

Resistant: C4 – Case Studies