^
Contact us  to learn more about
our Premium Content:  News alerts, weekly reports and conference planners
DRUG:

Undisclosed EGFR inhibitor

i
Other names: Undisclosed EGFR inhibitor
Associations
Trials
Company:
Dana-Farber Cancer Institute, SpringWorks Therap
Drug class:
EGFR inhibitor
Related drugs:
Associations
Trials
over1year
WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models. (PubMed, Neurooncol Adv)
The present preclinical study evaluated the novel EGFR inhibitor WSD-0922. We employed flank and orthotopic patient-derived xenograft models to characterize WSD-0922 and compare its efficacy to erlotinib, a potent EGFR inhibitor that failed to provide benefit for GBM patients...WSD-0922 treatment preferentially inhibited phosphorylation of several proteins, including those associated with EGFR inhibitor resistance and cell metabolism. WSD-0922 is a highly potent inhibitor of EGFR in GBM, and warrants further evaluation in clinical studies.
Preclinical • Journal
|
EGFR (Epidermal growth factor receptor)
|
erlotinib • WSD0922 • Undisclosed EGFR inhibitor