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BIOMARKER:

BRCA1 mutation + TP53 mutation

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Entrez ID:

Related biomarkers:

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TP53 mutation + Chr del(17p) (14)

HRD + BRCA1 mutation (7)

FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)

EML4-ALK variant 3 + TP53 mutation (5)

TP53 mutation + ALK positive (4)

BRCA wild-type + TP53 mutation (3)

TP53 mutation + Chr del(11q) (3)

BRCA1 mutation + HR positive (3)

BRCA1 mutation + TMB-H (3)

ALK fusion + TP53 mutation (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

EML4-ALK fusion + TP53 mutation (2)

HR positive + TP53 mutation (2)

BRCA1 2080delA + CCNE1 overexpression (2)

BRCA1 mutation + HER-2 negative (2)

HR negative + BRCA1 mutation (2)

HR positive + BRCA1 mutation (2)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK negative + TP53 deletion (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

CD74-ROS1 fusion + TP53 mutation (1)

CPE-ALK fusion + TP53 wild-type (1)

Chr del(5q) + TP53 expression (1)

Chr t(11;14) + TP53 mutation (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + TP53 mutation (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + TP53 expression (1)

FAT1 mutation + TP53 wild-type (1)

FLT3 wild-type + TP53 mutation (1)

FLT3-ITD mutation + MLL fusion + TP53 mutation (1)

GNA13 deletion + TP53 mutation (1)

HER-2 positive + TP53 mutation (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

KRAS G12D + TP53 deletion (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDH elevation + TP53 mutation (1)

LRP1B mutation + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MSI-H/dMMR + TP53 mutation (1)

MSLN overexpression + TP53 mutation (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

ROS1 fusion + TP53 mutation (1)

ROS1-CD74 fusion + TP53 K139N (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMEM87A-RASGRF1 fusion + TP53 R273H (1)

TP53 R280K + BRCA wild-type (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 deletion + RB1 deletion + CTSK expression (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + FGFR2 fusion (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TP53 wild-type + ER positive (1)

BAP1 negative + BRCA1 mutation (1)

BRCA1 hypermethylation (1)

BRCA1 mutation + AKR1C3 overexpression (1)

BRCA1 mutation + BRCA2 mutation + TMB-H (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA1 mutation + PD-L1 expression (1)

BRCA1 mutation + RAD51B deletion (1)

BRCA1 mutation + RB1 deletion (1)

BRCA1 promoter methylation (1)

EGFR mutation + BRCA1 overexpression (1)

EGFR mutation + BRCA1 underexpression (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

PTEN deletion + BRCA1 mutation (1)

FGFR2 K660N + TP53 deletion (0)

ER positive + BRCA1 mutation (0)

TP53 mutation + Chr del(17p) (14)

HRD + BRCA1 mutation (7)

FGF19 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF3 amplification + HRAS Q61R + TP53 672+2T>G (6)

FGF4 amplification + HRAS Q61R + TP53 672+2T>G (6)

EML4-ALK variant 3 + TP53 mutation (5)

TP53 mutation + ALK positive (4)

BRCA wild-type + TP53 mutation (3)

TP53 mutation + Chr del(11q) (3)

BRCA1 mutation + HR positive (3)

BRCA1 mutation + TMB-H (3)

ALK fusion + TP53 mutation (2)

EGFR exon 19 deletion + TP53 mutation + RB1 mutation (2)

EML4-ALK fusion + TP53 mutation (2)

HR positive + TP53 mutation (2)

BRCA1 2080delA + CCNE1 overexpression (2)

BRCA1 mutation + HER-2 negative (2)

HR negative + BRCA1 mutation (2)

HR positive + BRCA1 mutation (2)

ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)

ALK negative + TP53 deletion (1)

ALK positive + EML4-ALK fusion + TP53 mutation (1)

CD74-ROS1 fusion + TP53 mutation (1)

CPE-ALK fusion + TP53 wild-type (1)

Chr del(5q) + TP53 expression (1)

Chr t(11;14) + TP53 mutation (1)

EGFR exon 19 deletion + EGFR exon 21 mutation + TP53 mutation (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR exon 19 deletion + TP53 mutation + MET amplification (1)

EGFR exon 20 insertion + TP53 mutation (1)

EGFR expression + TP53 mutation (1)

EGFR mutation + MET amplification + TP53 mutation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + TP53 expression (1)

FAT1 mutation + TP53 wild-type (1)

FLT3 wild-type + TP53 mutation (1)

FLT3-ITD mutation + MLL fusion + TP53 mutation (1)

GNA13 deletion + TP53 mutation (1)

HER-2 positive + TP53 mutation (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)

KIF5B-RET fusion + TP53 H193R + MYC amplification (1)

KRAS G12D + TP53 deletion (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDH elevation + TP53 mutation (1)

LRP1B mutation + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type (1)

MDM2 amplification + TP53 wild-type + TWIST1 amplification (1)

MET amplification + TP53 mutation (1)

MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)

MSI-H/dMMR + TP53 mutation (1)

MSLN overexpression + TP53 mutation (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

ROS1 fusion + TP53 mutation (1)

ROS1-CD74 fusion + TP53 K139N (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMEM87A-RASGRF1 fusion + TP53 R273H (1)

TP53 R280K + BRCA wild-type (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 deletion + RB1 deletion + CTSK expression (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + FGFR2 fusion (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TP53 wild-type + ER positive (1)

BAP1 negative + BRCA1 mutation (1)

BRCA1 hypermethylation (1)

BRCA1 mutation + AKR1C3 overexpression (1)

BRCA1 mutation + BRCA2 mutation + TMB-H (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA1 mutation + PD-L1 expression (1)

BRCA1 mutation + RAD51B deletion (1)

BRCA1 mutation + RB1 deletion (1)

BRCA1 promoter methylation (1)

EGFR mutation + BRCA1 overexpression (1)

EGFR mutation + BRCA1 underexpression (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

PTEN deletion + BRCA1 mutation (1)

FGFR2 K660N + TP53 deletion (0)

ER positive + BRCA1 mutation (0)

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over2years

High grade acinic cell carcinoma of the breast with clear cytoplasm mimics clear cell carcinoma in a BRCA1 mutation carrier: a case report and review of the literature on the molecular analysis. (PubMed, Histol Histopathol)

Although she had bilateral high grade breast cancers, this patient refused postoperative adjuvant therapy this time and has been doing well in the past 12 months. As a rare form of triple-negative breast cancer with a relatively not so bad prognosis, more reports are needed to understand its biological characteristics.

over 2 years ago

Review • Journal • BRCA Biomarker

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HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • PGR (Progesterone receptor) • BRCA1 (Breast cancer 1, early onset)

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TP53 mutation • BRCA1 mutation • BRCA1 mutation + TP53 mutation

over2years

Clinical Utility of Next-generation Sequencing in Real-world Cases: A Single-institution Study of Nine Cases. (PubMed, In Vivo)

We recommend targeted NGS for the diagnoses and targeted therapy of cancer patients.

over 2 years ago

Retrospective data • Journal • Real-world evidence • Next-generation sequencing • BRCA Biomarker

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EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • MET (MET proto-oncogene, receptor tyrosine kinase) • BRCA1 (Breast cancer 1, early onset) • RET (Ret Proto-Oncogene) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • RB1 (RB Transcriptional Corepressor 1) • RAD51 (RAD51 Homolog A) • NCOA4 (Nuclear Receptor Coactivator 4)

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TP53 mutation • HER-2 mutation • RET fusion • MET exon 14 mutation • ROS1 fusion • NCOA4-RET fusion • BRCA1 mutation + TP53 mutation • RAD51 mutation