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    BIOMARKER:

    BRCA1 mutation + TP53 mutation

    i
    Other names: BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset, TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
    Entrez ID:
    7157; 672
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over2years
    High grade acinic cell carcinoma of the breast with clear cytoplasm mimics clear cell carcinoma in a BRCA1 mutation carrier: a case report and review of the literature on the molecular analysis. (PubMed, Histol Histopathol)
    Although she had bilateral high grade breast cancers, this patient refused postoperative adjuvant therapy this time and has been doing well in the past 12 months. As a rare form of triple-negative breast cancer with a relatively not so bad prognosis, more reports are needed to understand its biological characteristics.
    Review • Journal • BRCA Biomarker
    |
    HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • PGR (Progesterone receptor) • BRCA1 (Breast cancer 1, early onset)
    |
    TP53 mutation • BRCA1 mutation • BRCA1 mutation + TP53 mutation
    over2years
    Clinical Utility of Next-generation Sequencing in Real-world Cases: A Single-institution Study of Nine Cases. (PubMed, In Vivo)
    We recommend targeted NGS for the diagnoses and targeted therapy of cancer patients.
    Retrospective data • Journal • Real-world evidence • Next-generation sequencing • BRCA Biomarker
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • MET (MET proto-oncogene, receptor tyrosine kinase) • BRCA1 (Breast cancer 1, early onset) • RET (Ret Proto-Oncogene) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • RB1 (RB Transcriptional Corepressor 1) • RAD51 (RAD51 Homolog A) • NCOA4 (Nuclear Receptor Coactivator 4)
    |
    TP53 mutation • HER-2 mutation • RET fusion • MET exon 14 mutation • ROS1 fusion • NCOA4-RET fusion • BRCA1 mutation + TP53 mutation • RAD51 mutation